CAJ | 학술논문

目的评价霉酚酸酯(MMF)与间断性环磷酰胺(CTX)静脉冲击疗法治疗弥漫增生型狼疮性肾炎(DPLN)的有效性和安全性.方法检索PubMed、MEDLINE和中国期刊网等数据库,收集MMF与间断性CTX静脉冲击疗法治疗DPLN的随机对照试验14篇.使用RevMan 5.0软件分析评价临床总缓解率、复发率、病死率、疱疹的情况.结果患者临床总缓解率,MMF较间断性CTX静脉冲击疗法高(P＜0.05).而复发率、病死率、疱疹情况,差异无统计学意义(P＞0.05).结论 MMF治疗DPLN的有效性和安全性较间断性CTX静脉冲击疗法为优.
목적 평개매분산지(MMF)여간단성배린선알(CTX)정맥충격요법치료미만증생형랑창성신염(DPLN)적유효성화안전성.방법 검색PubMed、MEDLINE화중국기간망등수거고,수집MMF여간단성CTX정맥충격요법치료DPLN적수궤대조시험14편.사용RevMan 5.0연건분석평개림상총완해솔、복발솔、병사솔、포진적정황.결과 환자림상총완해솔,MMF교간단성CTX정맥충격요법고(P＜0.05).이복발솔、병사솔、포진정황,차이무통계학의의(P＞0.05).결론 MMF치료DPLN적유효성화안전성교간단성CTX정맥충격요법위우.
Objective To estimate the application of mycophenolate mofetil (MMF) and cyclophosphamide(CTX) intravenous pulse therapy on diffuse proliferative lupus nephritis (DPLN).Method PubMed,Medline,EMBASE and CNKI were searched from the establishment of the database.Meta-analysis of 14 comparative studies on MMF and CTX in treatment of DPLN was performed,taking the remission,the relapse,the death of MMF and CTX for DPLN as primary efficacy variable,mean while taking the herpes zoster as safety evaluating indicator.Results MMF was better than CTX in remission rate ( P ＜ 0.05 ).There was no difference between in incidence rate of the relapse,the death and the herpes zoste MMF and CTX for DPLN ( P ＞ 0.05 ).Conclusion MMF was better than CTX on the efficacy and safety in DPLN.