中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2011年
2期
152-155
,共4页
俞文华%惠国桢%车志豪%李向东%许培源%朱强%张祖勇%杜权%董晓巧%王昊
俞文華%惠國楨%車誌豪%李嚮東%許培源%硃彊%張祖勇%杜權%董曉巧%王昊
유문화%혜국정%차지호%리향동%허배원%주강%장조용%두권%동효교%왕호
垂体腺瘤%骨桥蛋白%CD44v6
垂體腺瘤%骨橋蛋白%CD44v6
수체선류%골교단백%CD44v6
Pituitary adenoma%Osteopontin%CD44v6
目的 检测骨桥蛋白(OPN)、CD44v6在垂体腺瘤中表达并探讨其与垂体腺瘤临床病理特征的关系.方法 应用免疫组化SP法检测80例垂体腺瘤组织中OPN和CD44v6蛋白的表达,并对二者表达与垂体腺瘤临床病理特征之间的关系进行分析.结果 OPN、CD44v6在垂体腺瘤中阳性表达率分别为66.3%、65.0%,OPN、CD44v6的表达均与患者的年龄、性别、肿瘤组织学类型无关,但在侵袭性垂体腺瘤组与非侵袭性垂体腺瘤组、复发组及非复发组之间的差异均有统计学意义(P＜0.01),而且二者在垂体腺瘤中表达呈正相关(r=0.585,P＜0.01).结论 OPN和CD44v6蛋白在垂体腺瘤中高表达与肿瘤侵袭性生长及复发相关,且两者在肿瘤侵袭性改变中可能起协同作用,二者联合检测有望更客观评价垂体腺瘤的侵袭性.
目的 檢測骨橋蛋白(OPN)、CD44v6在垂體腺瘤中錶達併探討其與垂體腺瘤臨床病理特徵的關繫.方法 應用免疫組化SP法檢測80例垂體腺瘤組織中OPN和CD44v6蛋白的錶達,併對二者錶達與垂體腺瘤臨床病理特徵之間的關繫進行分析.結果 OPN、CD44v6在垂體腺瘤中暘性錶達率分彆為66.3%、65.0%,OPN、CD44v6的錶達均與患者的年齡、性彆、腫瘤組織學類型無關,但在侵襲性垂體腺瘤組與非侵襲性垂體腺瘤組、複髮組及非複髮組之間的差異均有統計學意義(P＜0.01),而且二者在垂體腺瘤中錶達呈正相關(r=0.585,P＜0.01).結論 OPN和CD44v6蛋白在垂體腺瘤中高錶達與腫瘤侵襲性生長及複髮相關,且兩者在腫瘤侵襲性改變中可能起協同作用,二者聯閤檢測有望更客觀評價垂體腺瘤的侵襲性.
목적 검측골교단백(OPN)、CD44v6재수체선류중표체병탐토기여수체선류림상병리특정적관계.방법 응용면역조화SP법검측80례수체선류조직중OPN화CD44v6단백적표체,병대이자표체여수체선류림상병리특정지간적관계진행분석.결과 OPN、CD44v6재수체선류중양성표체솔분별위66.3%、65.0%,OPN、CD44v6적표체균여환자적년령、성별、종류조직학류형무관,단재침습성수체선류조여비침습성수체선류조、복발조급비복발조지간적차이균유통계학의의(P＜0.01),이차이자재수체선류중표체정정상관(r=0.585,P＜0.01).결론 OPN화CD44v6단백재수체선류중고표체여종류침습성생장급복발상관,차량자재종류침습성개변중가능기협동작용,이자연합검측유망경객관평개수체선류적침습성.
Objective To explore the expressions of osteopontin (OPN) and CD44v6 in pituitary adenomas and to evaluate the relationship between the expressions and invasiveness of the tumor.Methods Immunohistochemistry was used to detect the expressions of OPN and CD44v6 in 80 pituitary adenomas,and the relationships between the expressions of OPN and CD44v6 and the clinicopathologic characteristics were also analyzed.Methods The positive expression rates of OPN and CD44v6 were 66.3% and 65.0% respectively in the pituitary adenomas.Both OPN and CD44v6 expressions were different statistically in invasive group and recurrent group(P<0.01 ),but not correlated with patient' s age,sex and histological types.There was also a significantly positive relation between OPN and CD44v6 expression in pituitary adenomas (P<0.01 ).Conclusion The increased expressions of OPN and CD44v6 are associated with the invasiveness and recurrence of pituitary adenomas.They might have a synergetic effect in the invasive growth of the tumor,which can be taken as leading candidates for evaluating the biological behavior.
