CAJ | 학술논문

目的探讨超声内镜引导下5-FU化疗粒子植入治疗进展期胃癌的临床价值.方法选择进展期胃癌病灶伴流出道梗阻的病例,在超声胃镜引导下进行多点植入5-FU化疗粒子45～60粒,平均注射5-FU化疗粒子100 mg,并进行治疗前后的病灶三维扫描.结果 23例患者共施行粒子植入治疗33次.内镜观察标准完全缓解1例,部分缓解15例,稳定6例,恶化1例.临床上缓解不全梗阻显著有效6例,明显有效7例,有效9例,无效2例,总有效率91.4%.结论超声内镜引导下5-FU化疗粒子植入治疗进展期胃癌安全、可靠,并发症少.超声内镜三维扫描对化疗疗效的判断可作为一种新的评价方法.
목적 탐토초성내경인도하5-FU화료입자식입치료진전기위암적림상개치.방법 선택진전기위암병조반류출도경조적병례,재초성위경인도하진행다점식입5-FU화료입자45～60립,평균주사5-FU화료입자100 mg,병진행치료전후적병조삼유소묘.결과 23례환자공시행입자식입치료33차.내경관찰표준완전완해1례,부분완해15례,은정6례,악화1례.림상상완해불전경조현저유효6례,명현유효7례,유효9례,무효2례,총유효솔91.4%.결론 초성내경인도하5-FU화료입자식입치료진전기위암안전、가고,병발증소.초성내경삼유소묘대화료료효적판단가작위일충신적평개방법.
Objective To evaluate the efficacy of endoscopic ultrasonography(EUS)guided implantation of 5-FU seeds for progressive gastric cancer.Methods A total of 23 patients with progressive gastric cancer and outflow obstruction were enrolled into the study.During the endoscopy procedure, 45-60 5-FU seeds were implanted into the tumors with guidance of EUS, with an average dose of 100 mg.Volumes of tumor were examined with 3D-EUS before and after the treatment.Results A total of 33 procedures of 5-FU implantation were performed.By measurements of 3D-EUS, the numbers of patients with complete respons, partial response, no change, progressive disease were 1, 15, 6 and 1, respectively.In terms of outflow obstruction improvement, significant effect, obvious effect and average effect were achieved in 6, 7 and 9 patients, respectively, with an overall response rate at 91.4%.Conclusion EUS-guided 5-FU seed implantation in progressive gastric cancer is safe,reliable and effective with few complications.3D-EUS may be a new method to evaluate curative effect.