生物物理学报
生物物理學報
생물물이학보
ACTA BIOPHYSICA SINICA
2004年
6期
453-464
,共12页
万业宏%菅忠%文治洪%王玉英%胡三觉
萬業宏%菅忠%文治洪%王玉英%鬍三覺
만업굉%관충%문치홍%왕옥영%호삼각
短簇脉冲%单个脉冲%事件间间隔%回归映射%互信息
短簇脈遲%單箇脈遲%事件間間隔%迴歸映射%互信息
단족맥충%단개맥충%사건간간격%회귀영사%호신식
Brief burst%Single pulse%Interevent intervals (IEIs)%Return map%Mutual information
外周感觉神经元通过动作电位序列对信号进行编码,这些动作电位序列经过突触传递最终到达脑部.但是各种脉冲序列如何通过神经元之间的化学突触进行传递依然是一个悬而未决的问题.研究了初级传入Aδ纤维与背角神经元之间各种动作电位序列的突触传递过程.用于刺激的规则、周期、随机脉冲序列由短簇脉冲或单个脉冲构成.定义"事件"(event)为峰峰间期(interspike interval)小于或等于规定阈值的最长动作电位串,然后从脉冲序列中提取事件间间期(in-terevent interval,IEI).用时间-IEI图与回归映射的方法分析IEI序列,结果表明在突触后输出脉冲序列中可以检测到突触前脉冲序列的主要时间结构特征,特别是在短簇脉冲作为刺激单位时.通过计算输入与输出脉冲序列的互信息,发现短簇脉冲可以更可靠地跨突触传递由输入序列携带的神经信息.这些结果表明外周输入脉冲序列的主要时间结构特征可以跨突触传递,在突触传递神经信息的过程中短簇脉冲更为有效.这一研究在从突触传递角度探索神经信息编码方面迈出了一步.
外週感覺神經元通過動作電位序列對信號進行編碼,這些動作電位序列經過突觸傳遞最終到達腦部.但是各種脈遲序列如何通過神經元之間的化學突觸進行傳遞依然是一箇懸而未決的問題.研究瞭初級傳入Aδ纖維與揹角神經元之間各種動作電位序列的突觸傳遞過程.用于刺激的規則、週期、隨機脈遲序列由短簇脈遲或單箇脈遲構成.定義"事件"(event)為峰峰間期(interspike interval)小于或等于規定閾值的最長動作電位串,然後從脈遲序列中提取事件間間期(in-terevent interval,IEI).用時間-IEI圖與迴歸映射的方法分析IEI序列,結果錶明在突觸後輸齣脈遲序列中可以檢測到突觸前脈遲序列的主要時間結構特徵,特彆是在短簇脈遲作為刺激單位時.通過計算輸入與輸齣脈遲序列的互信息,髮現短簇脈遲可以更可靠地跨突觸傳遞由輸入序列攜帶的神經信息.這些結果錶明外週輸入脈遲序列的主要時間結構特徵可以跨突觸傳遞,在突觸傳遞神經信息的過程中短簇脈遲更為有效.這一研究在從突觸傳遞角度探索神經信息編碼方麵邁齣瞭一步.
외주감각신경원통과동작전위서렬대신호진행편마,저사동작전위서렬경과돌촉전체최종도체뇌부.단시각충맥충서렬여하통과신경원지간적화학돌촉진행전체의연시일개현이미결적문제.연구료초급전입Aδ섬유여배각신경원지간각충동작전위서렬적돌촉전체과정.용우자격적규칙、주기、수궤맥충서렬유단족맥충혹단개맥충구성.정의"사건"(event)위봉봉간기(interspike interval)소우혹등우규정역치적최장동작전위천,연후종맥충서렬중제취사건간간기(in-terevent interval,IEI).용시간-IEI도여회귀영사적방법분석IEI서렬,결과표명재돌촉후수출맥충서렬중가이검측도돌촉전맥충서렬적주요시간결구특정,특별시재단족맥충작위자격단위시.통과계산수입여수출맥충서렬적호신식,발현단족맥충가이경가고지과돌촉전체유수입서렬휴대적신경신식.저사결과표명외주수입맥충서렬적주요시간결구특정가이과돌촉전체,재돌촉전체신경신식적과정중단족맥충경위유효.저일연구재종돌촉전체각도탐색신경신식편마방면매출료일보.
Peripheral sensory neurons encode continuous, time-varying signals into spike trains, which are finally relayed to the brain through synaptic transmission. But how various types of spike trains are transmitted across chemical synapses between neurons is still an open question. Here the synaptic transmission of various spike trains between primary Aδ afferent fiber and spinal dorsal horn neuron was investigated. Regular, periodic and stochastic stimulus trains were composed of either brief bursts or single pulses. "Events" were defined as the longest sequences of spikes with all interspike intervals less than or equal to a certain threshold and the interevent intervals (IEIs) were extracted from spike trains. The IEI analysis by time-IEI graphs and return maps showed that the main temporal structure of presynaptic input trains could be detected in postsynaptic output trains, especially under brief-burst stimulation. By calculating the mutual information between input and output trains, it was found that brief bursts could more reliably transmit the information carried by input trains across synapses.These results suggested that the main temporal characters of peripheral input trains can be transmitted across synapses, and that brief-burst firing is more effective during synapse transmission of neural information. The present research takes a step forward to exploring the mystery of neural coding from the aspect of synaptic transmission.