CAJ | 학술논문

骨髓间充质干细胞是一类骨髓来源的成体干细胞,其生长、增殖行为受到多种环境因素的影响.胞外基质、细胞因子、机械刺激等理化因素对骨髓间充质干细胞的生长和增殖起着重要的调节作用,这些调节因素通过不同的信号转导途径影响骨髓间充质干细胞增殖,但又常常出现交叉对话、相互影响.就胞外基质、细胞因子和机械刺激影响骨髓间充质干细胞的增殖及其相应信号转导途径的研究进展作一简要综述.
골수간충질간세포시일류골수래원적성체간세포,기생장、증식행위수도다충배경인소적영향.포외기질、세포인자、궤계자격등이화인소대골수간충질간세포적생장화증식기착중요적조절작용,저사조절인소통과불동적신호전도도경영향골수간충질간세포증식,단우상상출현교차대화、상호영향.취포외기질、세포인자화궤계자격영향골수간충질간세포적증식급기상응신호전도도경적연구진전작일간요종술.
Bone marrow-derived mesenchymal stem cells (MSCs) are a kind of somatic stem cells. Many physical and chemical factors, such as extracellular matrix, cytokine and mechanical stimulation, play an important role in the proliferation of the cells through various signal transduction pathways. Meanwhile, it often presents cross-talking and interaction among those pathways. This paper focused on the review of the progress of the extracellular matrix, cytokine and mechanical stimulation on the proliferation of MSCs and their signal transduction.