中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2008年
3期
27-28
,共2页
彩色多普勒血流显像%糖尿病视网膜病变%球后血流动力学
綵色多普勒血流顯像%糖尿病視網膜病變%毬後血流動力學
채색다보륵혈류현상%당뇨병시망막병변%구후혈류동역학
Color Doppler flow imaging%Diabetic retinopathy%Hemodynamics
目的 探讨糖尿病(DM)患者血糖控制不良在视网膜病变(DR)发生发展中的作用.方法 应用彩色多普勒血流显像(CDFI)检测72例DM患者和26例正常对照组眼动脉(OA)、视网膜中央动脉(CRA)的各项参数.结果 在DR发生过程中的不伴DR组,眼底荧光造影尚未发现明显病变时,CRA血流速度较对照组增高(P＜0.05),非增殖期DR组接近对照组(P＞0.05),增殖期DR组低于对照组(P＜0.05)并伴有OA舒张末期血流速度下降及阻力指数增高;DM不伴DR者或DR早期CRA血流速度与糖化血红蛋白(HbAle)水平呈正相关,DR越重血糖水平对CRA血流速度的影响越小.结论 CDFI是评价DR时OA、CRA的血流动力学变化的有效方法,持续而有效地血糖控制是DR治疗的首要措施.
目的 探討糖尿病(DM)患者血糖控製不良在視網膜病變(DR)髮生髮展中的作用.方法 應用綵色多普勒血流顯像(CDFI)檢測72例DM患者和26例正常對照組眼動脈(OA)、視網膜中央動脈(CRA)的各項參數.結果 在DR髮生過程中的不伴DR組,眼底熒光造影尚未髮現明顯病變時,CRA血流速度較對照組增高(P＜0.05),非增殖期DR組接近對照組(P＞0.05),增殖期DR組低于對照組(P＜0.05)併伴有OA舒張末期血流速度下降及阻力指數增高;DM不伴DR者或DR早期CRA血流速度與糖化血紅蛋白(HbAle)水平呈正相關,DR越重血糖水平對CRA血流速度的影響越小.結論 CDFI是評價DR時OA、CRA的血流動力學變化的有效方法,持續而有效地血糖控製是DR治療的首要措施.
목적 탐토당뇨병(DM)환자혈당공제불량재시망막병변(DR)발생발전중적작용.방법 응용채색다보륵혈류현상(CDFI)검측72례DM환자화26례정상대조조안동맥(OA)、시망막중앙동맥(CRA)적각항삼수.결과 재DR발생과정중적불반DR조,안저형광조영상미발현명현병변시,CRA혈류속도교대조조증고(P＜0.05),비증식기DR조접근대조조(P＞0.05),증식기DR조저우대조조(P＜0.05)병반유OA서장말기혈류속도하강급조력지수증고;DM불반DR자혹DR조기CRA혈류속도여당화혈홍단백(HbAle)수평정정상관,DR월중혈당수평대CRA혈류속도적영향월소.결론 CDFI시평개DR시OA、CRA적혈류동역학변화적유효방법,지속이유효지혈당공제시DR치료적수요조시.
Objective To investigate the role of lasting hyperglycemia in the pathogenesis of diabetic retinopathy (DR) in patients with diabetes mellitus (DM). Methods The ophthalmic artery's (OA) and central retinal artery's (CRA) hemodynamics were studied with color Doppler flow imaging (CDFI) in 72 DM cases and 26 normal volunteers. Results In the very early stage of the course of DR even no slight pathological change was able to be observed by the fundus fluorescein angiography, the blood flow of CRA was already increased, higher than that in the control group(P ＜0.05), while in back ground DR stage, the blood flow velocity of CRA was almost as high as that in the control group (P＞0.05), but in proliferate DR stages the blood flow was lower than that in the control group (P＜0.05), accompanied by the lower OA Vmin and a higher OA resistance index (RI). In the DM patients without DR or with early DR the blood flow of CRA was correlated to glucosylated hemoglobin AIc (HbAlc) positively. At this stage the severe the DR is, the less is the level of HbAlc influenced the blood flow velocity in CRA. Conclusion CDFI is proved to be an effective method in evaluation of CRA hemodynamics in DR, and stable glycemia controlled is essential in DR treatment.
