CAJ | 학술논문

目的对比分析宫颈癌常规计划和逆向计划（即模拟退火逆向优化计划）的剂量学差异。方法选取宫颈癌内外照射联合根治性放疗的患者20例，每例患者制定两个治疗计划：一个为基于A点给定处方剂量的常规计划；另一个为逆向计划，先满足靶区，优化时，当临床靶区(CTV)的90％处方剂量体积大于90％ CTV时即达到优化目标，否则调节目标函数的权重配比，重新优化，直到达到优化目标。结果逆向计划的90％处方剂量体积和100％处方剂量体积及100％目标体积受量[(94±15)％、(90±18)％、(54±10)％]均优于常规计划[(60±17)％、(56±14)％、(29±9)％](P＜0.05),同时危及器官亦得到较好的保护。结论逆向优化的治疗计划具有节省时间，提高靶区剂量，减少危及器官受量的优势。
목적대비분석궁경암상규계화화역향계화（즉모의퇴화역향우화계화）적제량학차이。방법선취궁경암내외조사연합근치성방료적환자20례，매례환자제정량개치료계화：일개위기우A점급정처방제량적상규계화；령일개위역향계화，선만족파구，우화시，당림상파구(CTV)적90％처방제량체적대우90％ CTV시즉체도우화목표，부칙조절목표함수적권중배비，중신우화，직도체도우화목표。결과역향계화적90％처방제량체적화100％처방제량체적급100％목표체적수량[(94±15)％、(90±18)％、(54±10)％]균우우상규계화[(60±17)％、(56±14)％、(29±9)％](P＜0.05),동시위급기관역득도교호적보호。결론역향우화적치료계화구유절성시간，제고파구제량，감소위급기관수량적우세。
Objective To compare and analyze conventional plan and inverse optimized plan in dosemetric of cervical cancer. Method Twenty cases of cervical cancer treated with combination radical radiotherapy of EBT were selected,every case had two plans: one was conventional plan based A point prescription dose, the other was inverse optimized plan (IPSA, inverse planning with simulated annealing)based volume object dose. Results IPSA plans provided better values compared with the conventional plans in 90％ prescription dose volume V90[ (94 ± 15 )％ vs. (60 ± 17 )％], 100％ prescription dose volume V100[(90 ± 18)％ vs. (56 ± 14)％]and 100％ treatment volume dose D100[(54 ± 10)％ vs. (29 ±9)％](P ＜0.05),respectively. Meanwhile the organ at risk received lower dose volume. Conclusions Plans generated using IPSA provide higher dose to the target volume but with lower dose to normal structure and less time. This study can help to guide the clinical application.