中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2011年
9期
879-883
,共5页
赵辉林%许建荣%刘晓晟%路青%华佳
趙輝林%許建榮%劉曉晟%路青%華佳
조휘림%허건영%류효성%로청%화가
颈动脉疾病%动脉粥样硬化%磁共振成像
頸動脈疾病%動脈粥樣硬化%磁共振成像
경동맥질병%동맥죽양경화%자공진성상
Carotid artery diseases%Atherosclerosis%Magnetic resonance imaging
目的 通过与病理对照,探讨3.0T高分辨率MRI检测老年人离体颈动脉血管壁结构特征及对动脉粥样硬化病变形态学和定量分析的能力。方法 对9对(18根)老年人的离体颈动脉标本,在3.0 T MR仪上采用特制小孔径线圈行高分辨率T1WI、T2WI脂肪抑制扫描,测量血管截面的最大内膜厚度、管腔面积、内膜面积和中膜面积,并根据美国心脏病协会(AHA)动脉粥样斑块病理分型及MRI分型标准进行分型,进行病理与影像的Pearson和Spearman相关分析以及一致性Kappa检验。结果 以T2WI脂肪抑制序列显示的颈动脉管腔面积、中膜面积和内膜面积的病理组织学相关性较高[T2WI与病理测量分别为(27.53±6.77) mm2和(25.83 ±6.69)mm2,r2 =0.91,P2 =0.024;(12.31 ±3.31)mm2和( 12.28±3.71) mm2,r2 =0.70,P2 =0.020;中位数12.29 mm2(范围1.12~33.18 mm2)和11.62 mm2(范围0.89~32.84 mm2),r2 =0.74,P2 =0.016];颈动脉粥样硬化MRI分型与AHA病理分型结果具有较好的一致性(Kappa值=0.74,95%可信区间为0.67~0.80)。结论 3.0T高分辨率多序列MRI能清晰显示离体颈动脉血管壁的形态特征和细微结构并允许进行量化评估,尤其是T2WI脂肪抑制序列具有对动脉粥样硬化病变准确定位和分型的能力。
目的 通過與病理對照,探討3.0T高分辨率MRI檢測老年人離體頸動脈血管壁結構特徵及對動脈粥樣硬化病變形態學和定量分析的能力。方法 對9對(18根)老年人的離體頸動脈標本,在3.0 T MR儀上採用特製小孔徑線圈行高分辨率T1WI、T2WI脂肪抑製掃描,測量血管截麵的最大內膜厚度、管腔麵積、內膜麵積和中膜麵積,併根據美國心髒病協會(AHA)動脈粥樣斑塊病理分型及MRI分型標準進行分型,進行病理與影像的Pearson和Spearman相關分析以及一緻性Kappa檢驗。結果 以T2WI脂肪抑製序列顯示的頸動脈管腔麵積、中膜麵積和內膜麵積的病理組織學相關性較高[T2WI與病理測量分彆為(27.53±6.77) mm2和(25.83 ±6.69)mm2,r2 =0.91,P2 =0.024;(12.31 ±3.31)mm2和( 12.28±3.71) mm2,r2 =0.70,P2 =0.020;中位數12.29 mm2(範圍1.12~33.18 mm2)和11.62 mm2(範圍0.89~32.84 mm2),r2 =0.74,P2 =0.016];頸動脈粥樣硬化MRI分型與AHA病理分型結果具有較好的一緻性(Kappa值=0.74,95%可信區間為0.67~0.80)。結論 3.0T高分辨率多序列MRI能清晰顯示離體頸動脈血管壁的形態特徵和細微結構併允許進行量化評估,尤其是T2WI脂肪抑製序列具有對動脈粥樣硬化病變準確定位和分型的能力。
목적 통과여병리대조,탐토3.0T고분변솔MRI검측노년인리체경동맥혈관벽결구특정급대동맥죽양경화병변형태학화정량분석적능력。방법 대9대(18근)노년인적리체경동맥표본,재3.0 T MR의상채용특제소공경선권행고분변솔T1WI、T2WI지방억제소묘,측량혈관절면적최대내막후도、관강면적、내막면적화중막면적,병근거미국심장병협회(AHA)동맥죽양반괴병리분형급MRI분형표준진행분형,진행병리여영상적Pearson화Spearman상관분석이급일치성Kappa검험。결과 이T2WI지방억제서렬현시적경동맥관강면적、중막면적화내막면적적병리조직학상관성교고[T2WI여병리측량분별위(27.53±6.77) mm2화(25.83 ±6.69)mm2,r2 =0.91,P2 =0.024;(12.31 ±3.31)mm2화( 12.28±3.71) mm2,r2 =0.70,P2 =0.020;중위수12.29 mm2(범위1.12~33.18 mm2)화11.62 mm2(범위0.89~32.84 mm2),r2 =0.74,P2 =0.016];경동맥죽양경화MRI분형여AHA병리분형결과구유교호적일치성(Kappa치=0.74,95%가신구간위0.67~0.80)。결론 3.0T고분변솔다서렬MRI능청석현시리체경동맥혈관벽적형태특정화세미결구병윤허진행양화평고,우기시T2WI지방억제서렬구유대동맥죽양경화병변준학정위화분형적능력。
Objective To evaluate the ability of high resolution magnetic resonance (MR) imaging at 3.0 tesla to depict the characterization of human carotid arterial vessel wall and detect atherosclerotic lesions ex vivo in comparison to histopathologic results. Methods Eighteen carotid arteries obtained from 9 elderly donors underwent fat-suppressed T1 - and T2-weighted MR imaging at 3.0 tesla MR system with a mouse coil. Corresponding histological sections were obtained for the comparison. Correlation between MR images and histopathologic slices was obtained by Pearson or Spearman correlation coefficient. Cohen K was computed to quantify the agreement between MRI and histopathologic findings. Results Lumen area,intima and media area measured on fat-suppressed T2-weighted images showed stronger correlation with the corresponding histopathologic slices [ MRI vs. histopathology: ( 27. 53 ± 6. 77 ) mm2 vs. ( 25.83 ±6. 69 ) mm2, r2 = 0. 91,P2 = 0. 024, ( 12.31 ± 3. 31 ) mm2 vs. ( 12. 28 ± 3.71 ) mm2, r2 = 0. 70, P2 = 0. 020,Median 12. 29 mm2(Min 1.12 mm2, Max 33.18 mm2) vs. Median 11.62 mm2(Min 0.89 mm2, Max 32. 84 mm2 ), r2 = 0. 74, P2 = 0. 016, respectively]. The Cohen K score between the MR imaging and American Heart Association classifications was 0. 74, which corresponds to a good agreement. Conclusions 3.0 T high-resolution multi-sequence MRI can clearly show the structure of ex vivo carotid artery wall and allow quantitative assessment. Fat-suppressed T2W imaging has a greater advantage in presenting atherosclerotic lesions.