CAJ | 학술논문

目的探讨彩色多普勒超声检测叶间动脉血流动力学参数对慢性肾疾病(chronic kidney disease,CKD)的早期诊断价值.方法运用彩色多普勒超声对78例CKD患者和65例健康人的叶间动脉进行超声检查,测量收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、搏动指数(PI)、阻力指数(RI),同时进行血清胱抑素C(SCysC)的检测,观察早期CKD患者叶间动脉RI的变化规律并分析其与肾活检病理结果的相关性.结果 40例SCysC正常的CKD患者(A组)叶间动脉PSV、EDV、PI、RI与正常对照组比较差异无统计学意义(P＞0.05);38例SCysC增高的CKD患者(B组)叶间动脉RI明显高于A组和正常对照组(P＜0.05),PSV、EDV均明显低于A组和正常对照组(P＜0.05).RI正常者病变仅局限于肾小球,RI增高者病变已累及肾小管间质.结论叶间动脉RI联合SCysC是评估CKD患者肾早期损害的敏感指标.
목적 탐토채색다보륵초성검측협간동맥혈류동역학삼수대만성신질병(chronic kidney disease,CKD)적조기진단개치.방법 운용채색다보륵초성대78례CKD환자화65례건강인적협간동맥진행초성검사,측량수축기봉치류속(PSV)、서장말기혈류속도(EDV)、박동지수(PI)、조력지수(RI),동시진행혈청광억소C(SCysC)적검측,관찰조기CKD환자협간동맥RI적변화규률병분석기여신활검병리결과적상관성.결과 40례SCysC정상적CKD환자(A조)협간동맥PSV、EDV、PI、RI여정상대조조비교차이무통계학의의(P＞0.05);38례SCysC증고적CKD환자(B조)협간동맥RI명현고우A조화정상대조조(P＜0.05),PSV、EDV균명현저우A조화정상대조조(P＜0.05).RI정상자병변부국한우신소구,RI증고자병변이루급신소관간질.결론 협간동맥RI연합SCysC시평고CKD환자신조기손해적민감지표.
Objective To explore the value of color Doppler ultrasound detection renal interlobar arterial hemodynamic parameters for early diagnosis in patients with chronic kidney disease(CKD).MethodsSeventy-eight patients with CKD were undergone interlobar arterial hemodynamic parameters detection and 65 normal persons served as the control.The peak systolic velocity (PSV),end-diastolic velocity (EDV),pulsatility index(PI),resistive index (RI) of interlobar arterial and serum cystatin C (SCysC) were measured.The variation of RI and the correlation of renal interlobar arterial RI and pathological findings in early CKD was analyzed.Results In 40 CKD cases with normal SCysC(group A),the PSV,EDV,PI,RI of renal interlobar arterial were not statistically significant (P＞0.05).In 38 CKD cases with increased SCysC(group B),the RI of renal interlobar arterial were higher than those of group A and control group (P＜0.05),and the PSV and EDV were lower than those of group A and control group (P＜0.05).In cases of CKD with normal RI,the disease limited to the glomeruli;while the RI increased,the disease locate in the tubulointerstitial compartment.Conclusions Interlobar arterial RI united SCysC is a sensitive indicator in assessing early injury of chronic kidney disease.