中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
6期
474-477
,共4页
那娜%王奇金%黄勤%丁长花%冯正康%吴鸿%李慧%鲁瑾%徐茂锦%邹大进
那娜%王奇金%黃勤%丁長花%馮正康%吳鴻%李慧%魯瑾%徐茂錦%鄒大進
나나%왕기금%황근%정장화%풍정강%오홍%리혜%로근%서무금%추대진
糖基化终末产物,晚期%糖基化终末产物可溶性受体%糖尿病,2型%动脉内中膜厚度%强化治疗
糖基化終末產物,晚期%糖基化終末產物可溶性受體%糖尿病,2型%動脈內中膜厚度%彊化治療
당기화종말산물,만기%당기화종말산물가용성수체%당뇨병,2형%동맥내중막후도%강화치료
Glycosylation end-products,advanced%Soluble receptor of advanced glycosylation end-products%Diabetes mellitus,type 2%Intima-media thickness of arteries%Intensive control
目的 评估强化控制血糖、血压、血脂对于新诊断2型糖尿病患者的颈、股动脉内中膜厚度(IMT)、血清晚期糖基化终末产物(AGE)及其可溶性受体(sRAGE)水平的影响.方法跟踪随访132例新诊断2型糖尿病患者5年,分3组:强化血糖、血压控制组(20例),强化血糖、血压、血脂控制组(80例),常规治疗组(32例).记录颈、股动脉IMT及其他相关指标水平变化情况,测定实验终点各组血清AGE和sRAGE水平.结果长期强化治疗较常规治疗,可明显减少颈、股动脉IMT增厚,同时可有效抑制血清中AGE的蓄积(P=0.009).经多元回归分析提示AGE为股动脉IMT的独立危险因素.sRAGE与研究终点HbA1C水平的比值,与5年间HbA1C的均数及波动情况呈负相关(P＜0.05).结论长期强化治疗较常规治疗可明显减少2型糖尿病患者颈、股动脉IMT增厚,同时可减少AGE在其体内的累积.
目的 評估彊化控製血糖、血壓、血脂對于新診斷2型糖尿病患者的頸、股動脈內中膜厚度(IMT)、血清晚期糖基化終末產物(AGE)及其可溶性受體(sRAGE)水平的影響.方法跟蹤隨訪132例新診斷2型糖尿病患者5年,分3組:彊化血糖、血壓控製組(20例),彊化血糖、血壓、血脂控製組(80例),常規治療組(32例).記錄頸、股動脈IMT及其他相關指標水平變化情況,測定實驗終點各組血清AGE和sRAGE水平.結果長期彊化治療較常規治療,可明顯減少頸、股動脈IMT增厚,同時可有效抑製血清中AGE的蓄積(P=0.009).經多元迴歸分析提示AGE為股動脈IMT的獨立危險因素.sRAGE與研究終點HbA1C水平的比值,與5年間HbA1C的均數及波動情況呈負相關(P＜0.05).結論長期彊化治療較常規治療可明顯減少2型糖尿病患者頸、股動脈IMT增厚,同時可減少AGE在其體內的纍積.
목적 평고강화공제혈당、혈압、혈지대우신진단2형당뇨병환자적경、고동맥내중막후도(IMT)、혈청만기당기화종말산물(AGE)급기가용성수체(sRAGE)수평적영향.방법근종수방132례신진단2형당뇨병환자5년,분3조:강화혈당、혈압공제조(20례),강화혈당、혈압、혈지공제조(80례),상규치료조(32례).기록경、고동맥IMT급기타상관지표수평변화정황,측정실험종점각조혈청AGE화sRAGE수평.결과장기강화치료교상규치료,가명현감소경、고동맥IMT증후,동시가유효억제혈청중AGE적축적(P=0.009).경다원회귀분석제시AGE위고동맥IMT적독립위험인소.sRAGE여연구종점HbA1C수평적비치,여5년간HbA1C적균수급파동정황정부상관(P＜0.05).결론장기강화치료교상규치료가명현감소2형당뇨병환자경、고동맥IMT증후,동시가감소AGE재기체내적루적.
Objective To analyze the changes of the intima-media thickness(IMT)of carotid and femoral arteries, serum advanced glycosylation end-products(AGEs),and AGEs soluble receptor(sRAGE)after intensively controlling blood glucose, blood pressure, and lipid. Methods One hundred and thirty-two type 2 diabetic patients were divided into 3 groups and followed for 5 years: 20 patients were treated with intensive control of blood glucose and blood pressure, 80 patients with intensive control of blood glucose, blood pressure, and lipid; and 32 patients with conventional therapy. AGEs, sRAGE, and IMT of carotid and femoral arteries were measured and compared among different groups. Results The IMT of carotid and femoral arteries and serum level of AGEs were significantly decreased after intensive treatment. The ratio of sRAGE and HbA1C(sRAGE/HbA1C)were negatively correlated with the mean of HbA1Cin the past five years(r=-0.417, P＜0.001)and the fluctuation of HbA1C(r=-0.309,P＜0.001). Multinomial regression analysis showed that AGEs were the important risk factors of IMT of femoral artery(β=0.152,P=0.068). Conclusion Intensive treatment is significant in controlling the growing IMT of carotid and femoral arteries, while decreasing serum level of AGEs.
