中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
7期
562-565
,共4页
陈星霖%杨群芳%刘存飞%刘承云%符江琳%徐晓%雷映红
陳星霖%楊群芳%劉存飛%劉承雲%符江琳%徐曉%雷映紅
진성림%양군방%류존비%류승운%부강림%서효%뢰영홍
代谢综合征X%前列腺增生%高血压
代謝綜閤徵X%前列腺增生%高血壓
대사종합정X%전렬선증생%고혈압
Metabolic syndrome X%Prostatic hyperplasia%Hypertension
目的 回顾性分析老年代谢综合征(MS)与良性前列腺增生(BPH)的关系.方法 老年男性859名,其中单纯MS患者8例,单纯BPH患者619例,两种疾病并存者192例,未患病者40例.检测空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),并计算体质指数(BMI)、前列腺体积及前列腺年增长率(PG),分析代谢性危险因素与BPH的相关性.结果 BPH患者MS组与非MS组相比收缩压、舒张压、体质量、BMI、TG及FBG偏高(t=6.15、5.99、13.12、15.56、10.63、9.94,均P＜0.01),HDL-C浓度偏低(t=-7.57,P＜0.01);随着MS组分个数的增加,前列腺体积增加(F=2.98,P=0.031);随着年龄、体质量、BMI、收缩压、PG的增加,前列腺体积增大(t值分别为-6.39、-2.39、-2.36、-2.13、-25.85,均P＜0.05);前列腺体积与年龄、收缩压、体质量、BMI、血压升高呈正相关(r值分别为0.229、0.079、0.090、0.089、0.088,均P＜0.05);非条件Logistic回归分析校正混杂因素后,年龄、体质量和收缩压＞130 mm Hg(1 m Hg=0.133 kPa)为前列腺增生的独立相关因素(OR值分别为1.07、1.03、1.34,均P＜0.05).结论 老年患者BPH与MS有关,MS可能参与老年人BPH的发生发展过程,但其机制尚有待进一步研究.
目的 迴顧性分析老年代謝綜閤徵(MS)與良性前列腺增生(BPH)的關繫.方法 老年男性859名,其中單純MS患者8例,單純BPH患者619例,兩種疾病併存者192例,未患病者40例.檢測空腹血糖(FBG)、總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C),併計算體質指數(BMI)、前列腺體積及前列腺年增長率(PG),分析代謝性危險因素與BPH的相關性.結果 BPH患者MS組與非MS組相比收縮壓、舒張壓、體質量、BMI、TG及FBG偏高(t=6.15、5.99、13.12、15.56、10.63、9.94,均P＜0.01),HDL-C濃度偏低(t=-7.57,P＜0.01);隨著MS組分箇數的增加,前列腺體積增加(F=2.98,P=0.031);隨著年齡、體質量、BMI、收縮壓、PG的增加,前列腺體積增大(t值分彆為-6.39、-2.39、-2.36、-2.13、-25.85,均P＜0.05);前列腺體積與年齡、收縮壓、體質量、BMI、血壓升高呈正相關(r值分彆為0.229、0.079、0.090、0.089、0.088,均P＜0.05);非條件Logistic迴歸分析校正混雜因素後,年齡、體質量和收縮壓＞130 mm Hg(1 m Hg=0.133 kPa)為前列腺增生的獨立相關因素(OR值分彆為1.07、1.03、1.34,均P＜0.05).結論 老年患者BPH與MS有關,MS可能參與老年人BPH的髮生髮展過程,但其機製尚有待進一步研究.
목적 회고성분석노년대사종합정(MS)여량성전렬선증생(BPH)적관계.방법 노년남성859명,기중단순MS환자8례,단순BPH환자619례,량충질병병존자192례,미환병자40례.검측공복혈당(FBG)、총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C),병계산체질지수(BMI)、전렬선체적급전렬선년증장솔(PG),분석대사성위험인소여BPH적상관성.결과 BPH환자MS조여비MS조상비수축압、서장압、체질량、BMI、TG급FBG편고(t=6.15、5.99、13.12、15.56、10.63、9.94,균P＜0.01),HDL-C농도편저(t=-7.57,P＜0.01);수착MS조분개수적증가,전렬선체적증가(F=2.98,P=0.031);수착년령、체질량、BMI、수축압、PG적증가,전렬선체적증대(t치분별위-6.39、-2.39、-2.36、-2.13、-25.85,균P＜0.05);전렬선체적여년령、수축압、체질량、BMI、혈압승고정정상관(r치분별위0.229、0.079、0.090、0.089、0.088,균P＜0.05);비조건Logistic회귀분석교정혼잡인소후,년령、체질량화수축압＞130 mm Hg(1 m Hg=0.133 kPa)위전렬선증생적독립상관인소(OR치분별위1.07、1.03、1.34,균P＜0.05).결론 노년환자BPH여MS유관,MS가능삼여노년인BPH적발생발전과정,단기궤제상유대진일보연구.
Objective To retrospectively analyze the relationship between benign prostatic hyperplasia (BPH) and metabolic syndrome (MS) in senior patients. Methods The 859 male senior patients including 619 cases with BPH and 8 cases with MS were enrolled in this study, and there were 192 cases with both diseases and 40 controls. The levels of fasting blood glucose (FBG), total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured. The body mass index (BMI), prostate volume and annual prostate growth rate were determined or calculated. The correlations of BPH with other metabolic risk factors were analyzed. Results The levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight, BMI, TG and FPG were higher (t=6.15, 5.99, 13.12, 15.56, 10.63 and 9.94, all P＜0.01), while serum HDL-C level was lower (t=-7.57,P＜0.01) in BPH patients with MS than without MS. As the number of components of MS was increased, the prostate volume was increased (F=2.98, P=0.031). As the age, body weight, BMI, SBP and PG were increased, the prostate volume was increased (t=-6.39,-2.39,-2.36,-2.13,-25.85,all P＜0.05). Spearman analysis showed that prostate volume was positively correlated with age, SBP, body weight, BMI and hypertension (r=0.229, 0.079, 0.090, 0.089 and 0.088, all P＜0.05). And age, body weight and SBP were the independent risk factors for BPH (OR=1.07, 1.03 and 1.34, all P＜0.05). Conclusions The present study demonstrates a relationship between BPH and MS in senior patients. Future studies are needed to confirm our results and to explain underlying mechanisms.
