CAJ | 학술논문

目的:探讨人类白细胞抗原(human leucocyte antigen,HLA)HLA-A、B等位基因多态性与急性淋巴细胞白血病的相关性.方法:采用Luminex流式细胞术-序列特异性寡核苷酸探针(flow cytometry-sequence specific oligonucleotide probe,FLOW-SSOP)反向杂交方法对内蒙古地区48例急性淋巴细胞白血病病人HLA-A、B等位基因多态性进行分析,以北方地区健康群体资料作为正常对照.结果:(1)在HLA-A等位基因中,急性淋巴细胞白血病A*31XX、A*6901等位基因频率高于对照组(1.955%、0.071%),差异有统计学意义(P＜0.05);A*33XX等位基因频率低于对照组(5.825%),差异有统计意义(P＜0.05);(2)在HLA-B等位基因中,急性淋巴细胞白血病B*07XX、*27XX、*38XX、*41XX、*49XX、*59XX等位基因频率高于对照组(2.069%、0.968%、0.702%、0.091%、0.051%、0.061%),差异有统计学意义(P＜0.05);其中HLA-B*59XX的相对风险度高(RR=35.156),其它等位基因频率在两组之间无显著性差异.结论:HLA-A*31XX、A*6901;B*07XX、B*27XX、B*38XX、B*41XX、B*49XX、B*59XX等位基因与ALL相关联,有遗传易感作用.HLA-B*59XX等位基因携带者,可能患ALL的风险度增高(RR=35.156).
목적:탐토인류백세포항원(human leucocyte antigen,HLA)HLA-A、B등위기인다태성여급성림파세포백혈병적상관성.방법:채용Luminex류식세포술-서렬특이성과핵감산탐침(flow cytometry-sequence specific oligonucleotide probe,FLOW-SSOP)반향잡교방법대내몽고지구48례급성림파세포백혈병병인HLA-A、B등위기인다태성진행분석,이북방지구건강군체자료작위정상대조.결과:(1)재HLA-A등위기인중,급성림파세포백혈병A*31XX、A*6901등위기인빈솔고우대조조(1.955%、0.071%),차이유통계학의의(P＜0.05);A*33XX등위기인빈솔저우대조조(5.825%),차이유통계의의(P＜0.05);(2)재HLA-B등위기인중,급성림파세포백혈병B*07XX、*27XX、*38XX、*41XX、*49XX、*59XX등위기인빈솔고우대조조(2.069%、0.968%、0.702%、0.091%、0.051%、0.061%),차이유통계학의의(P＜0.05);기중HLA-B*59XX적상대풍험도고(RR=35.156),기타등위기인빈솔재량조지간무현저성차이.결론:HLA-A*31XX、A*6901;B*07XX、B*27XX、B*38XX、B*41XX、B*49XX、B*59XX등위기인여ALL상관련,유유전역감작용.HLA-B*59XX등위기인휴대자,가능환ALL적풍험도증고(RR=35.156).