CAJ | 학술논문

目的比较单用多巴丝肼与合用普拉克索治疗帕金森病两种方法效果.方法采用对照研究方法,比较多巴丝肼治疗组(A组)及合用普拉克索治疗组(B组)的治疗效果及治疗成本.结果 B组虽然在药物费用及治疗费用方面较A组明显增加(P＜0.01),但其帕金森病综合量表评分显著下降(P＜0.05),而且在帕金森病各期均可应用.结论联合应用普拉克索虽会加重药物成本及治疗成本,但在改善帕金森病各期临床症状方面效果更好,且可应用于不同分期的帕金森病患者,应个体化推荐.
목적 비교단용다파사정여합용보랍극색치료파금삼병량충방법효과.방법 채용대조연구방법,비교다파사정치료조(A조)급합용보랍극색치료조(B조)적치료효과급치료성본.결과 B조수연재약물비용급치료비용방면교A조명현증가(P＜0.01),단기파금삼병종합량표평분현저하강(P＜0.05),이차재파금삼병각기균가응용.결론 연합응용보랍극색수회가중약물성본급치료성본,단재개선파금삼병각기림상증상방면효과경호,차가응용우불동분기적파금삼병환자,응개체화추천.
Objective To assess cost-effectiveness of pramipexole and levodopa/benseraside in the hospitalized Parkinson's disease (PD) patient.Methods 81 PD patients were divided into group A(levodopa/benserazide group) and group B( pramipexole combined with levodopa/benserazide group) according to different pharmacotherapy.The curative effects and costs of hospitalized PD patients were evaluated.The curative effects were evaluated by unified Parkinson's disease rating scale (UPDRS).Results There were 44 patients in group A and 37 patients in group B.Although B group in drug costs and treatment costs were increased more significantly than A group ( P ＜0.01),but declined markedly UPDRS after treatment ( P ＜ 0.05 ) than A group.Pramipexole can be applied in all kinds of Hoehn and Yahr states in PD.Conclusion Although the combination of pramipexole would increase drug costs and treatment costs,but could improve the clinical symptoms of PD,and can be applied to different stages of PD.It should be individualized recommendation in the Parkinson's patients.