CAJ | 학술논문

目的研究慢性阻塞性肺疾病(COPD)患者血浆生长素释放肽(ghrelin)水平及其与营养状态的相关性,探讨ghrelin在COPD营养代谢中的作用.方法检测53例COPD患者[营养不良组(COPD A组)31例,营养正常组(COPD B组)22例]及20例健康对照组的血浆生长素释放肽水平,并测量体重指数,理想体质量百分比,上臂中部臂围、血清白蛋白、血淋巴细胞计数等评估营养状况,分析血浆生长素释放肽与各营养参数的相关性.结果营养不良组COPD血浆生长素释放肽水平高于营养正常组COPD和健康对照组,且其水平与体重指数、理想体质量百分比、上臂中部臂围呈负相关,而与血清白蛋白、血总淋巴细胞计数无相关性.结论血浆生长素释放肽参与了COPD患者营养不良状况的调节,其升高是机体在营养不良状态下机体反馈性生理调节的结果.
목적 연구만성조새성폐질병(COPD)환자혈장생장소석방태(ghrelin)수평급기여영양상태적상관성,탐토ghrelin재COPD영양대사중적작용.방법 검측53례COPD환자[영양불량조(COPD A조)31례,영양정상조(COPD B조)22례]급20례건강대조조적혈장생장소석방태수평,병측량체중지수,이상체질량백분비,상비중부비위、혈청백단백、혈림파세포계수등평고영양상황,분석혈장생장소석방태여각영양삼수적상관성.결과 영양불량조COPD혈장생장소석방태수평고우영양정상조COPD화건강대조조,차기수평여체중지수、이상체질량백분비、상비중부비위정부상관,이여혈청백단백、혈총림파세포계수무상관성.결론 혈장생장소석방태삼여료COPD환자영양불량상황적조절,기승고시궤체재영양불량상태하궤체반궤성생리조절적결과.
Objective To investigate the correlation between the serum ghrelin levels and nutrition state in the patients with chronic obstructive pulmonary disease(COPD) ,as well as to explore the role of ghxelin in the nutri-tion metabolism. Methods Fifty-three COPD patients were observed, thirty-one of them were with malnutrition (group A), twenty-two COPD patients with normal nutrition status(group B), and twenty were healthy controls.Serum ghrelin, and nutritional parameters such as body mass index(BMI), ideal body weitht( % IBW), mid-upper arm cricumference(MAC), serum albumin(ALB), total lymphocyte counts(LYM) were determined. The correlation between ghrelin and nutritional parameters was analysed. Resuits The level of serum ghrelin in group A were sig-nificantly higher than those in group B and in healthy controls. And the serum ghrelin showed a negative correlation with BMI, % IBW, MAC, but there was no correlation between serum ghrelin level, ALB and LYM. Conclusion Ghrelin participated in the nutrition metabolism in patients with COPD, it would become much higher because of malnutrition in COPD.