CAJ | 학술논문

人巨细胞病毒(HCMV)在人群中感染非常普遍,对于免疫功能正常的人来说通常是不显性感染或潜伏感染,但胎儿及免疫缺陷患者感染可导致极高的病死率.目前,关于HCMV先天感染的致病机制还不十分清楚.HCMV UL146基因编码α趋化因子同源物,其核苷酸及氨基酸序列的变异和蛋白趋化因子功能区的高度保守提示这个功能区对于HCMV具有重要的生物学意义.
인거세포병독(HCMV)재인군중감염비상보편,대우면역공능정상적인래설통상시불현성감염혹잠복감염,단태인급면역결함환자감염가도치겁고적병사솔.목전,관우HCMV선천감염적치병궤제환불십분청초.HCMV UL146기인편마α추화인자동원물,기핵감산급안기산서렬적변이화단백추화인자공능구적고도보수제시저개공능구대우HCMV구유중요적생물학의의.
Human cytomegalovirus (HCMV) infection is very common in the population. The form of infection usually presents silent or latent infection in the persons with normal immune function, but it can lead to a high mortality in the fetuses and the patients with immune deficiency. At present,the pathogenesis of the congenital infection by HCMV is not very clear. In the α chemokine homologue encoded by HCMV UL146, the variation of the nucleotide and amino acid sequences and the highly conservative domain suggests that this domain is important for HCMV in biological significance. And the study on the gene polymorphism and the function of its encoding protein will play an important role to reveal the pathogenesis of HCMV.