中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
12期
29-31
,共3页
胃肿瘤%辅助化疗%空肠穿刺置管%肠内营养
胃腫瘤%輔助化療%空腸穿刺置管%腸內營養
위종류%보조화료%공장천자치관%장내영양
Stomach neoplasms%Adjuvant chemotherapy%Needle catheter jejunostomy%Enteral nutrition
目的 研究延期留置空肠造口管间断肠内营养在进展期胃癌术后辅助化疗中应用的可行性及疗效.方法 将进展期胃癌术后行辅助化疗的82例患者按机械抽样法随机分成A、B两组,每组各41例.均于术中放置空肠造口管,A组延期留置空肠造口管至化疗6个疗程结束,每个化疗疗程经空肠造口管给予肠内营养液;B组于化疗前拔除空肠造口管,每个化疗疗程给予普通饮食.比较化疗后两组营养及免疫指标,观察延期留置空肠造口管相关并发症.结果 化疗后A组血红蛋白[(106.9±12.0)g/L]、血清白蛋白[(26.2±1.4)g/L]、前白蛋白[(202.9±32.2)mg/L]及IL-2[(11.9±2.1)μg/L]、NK细胞活性[(21.3±5.2)%]、CD:[(62.9±3.3)%]、CD4+[(26.1±4.7)%]、CD4/CD8(1.1±0.2)水平显著高于B组(P＜0.05或＜0.01);化疗期间A组呕吐发生率(4.9%,2/41)显著低于B组(26.8%,11/41),平均每日摄入量[(1312±114)ml]显著多于B组[(765±186)ml](P＜0.05).延期留置空肠造口管未发生相关严重并发症.结论 延期留置空肠造口管间断肠内营养在进展期胃癌术后辅助化疗中应用是安全可行的,可以有效地提高术后辅助化疗患者的营养及免疫状况.
目的 研究延期留置空腸造口管間斷腸內營養在進展期胃癌術後輔助化療中應用的可行性及療效.方法 將進展期胃癌術後行輔助化療的82例患者按機械抽樣法隨機分成A、B兩組,每組各41例.均于術中放置空腸造口管,A組延期留置空腸造口管至化療6箇療程結束,每箇化療療程經空腸造口管給予腸內營養液;B組于化療前拔除空腸造口管,每箇化療療程給予普通飲食.比較化療後兩組營養及免疫指標,觀察延期留置空腸造口管相關併髮癥.結果 化療後A組血紅蛋白[(106.9±12.0)g/L]、血清白蛋白[(26.2±1.4)g/L]、前白蛋白[(202.9±32.2)mg/L]及IL-2[(11.9±2.1)μg/L]、NK細胞活性[(21.3±5.2)%]、CD:[(62.9±3.3)%]、CD4+[(26.1±4.7)%]、CD4/CD8(1.1±0.2)水平顯著高于B組(P＜0.05或＜0.01);化療期間A組嘔吐髮生率(4.9%,2/41)顯著低于B組(26.8%,11/41),平均每日攝入量[(1312±114)ml]顯著多于B組[(765±186)ml](P＜0.05).延期留置空腸造口管未髮生相關嚴重併髮癥.結論 延期留置空腸造口管間斷腸內營養在進展期胃癌術後輔助化療中應用是安全可行的,可以有效地提高術後輔助化療患者的營養及免疫狀況.
목적 연구연기류치공장조구관간단장내영양재진전기위암술후보조화료중응용적가행성급료효.방법 장진전기위암술후행보조화료적82례환자안궤계추양법수궤분성A、B량조,매조각41례.균우술중방치공장조구관,A조연기류치공장조구관지화료6개료정결속,매개화료료정경공장조구관급여장내영양액;B조우화료전발제공장조구관,매개화료료정급여보통음식.비교화료후량조영양급면역지표,관찰연기류치공장조구관상관병발증.결과 화료후A조혈홍단백[(106.9±12.0)g/L]、혈청백단백[(26.2±1.4)g/L]、전백단백[(202.9±32.2)mg/L]급IL-2[(11.9±2.1)μg/L]、NK세포활성[(21.3±5.2)%]、CD:[(62.9±3.3)%]、CD4+[(26.1±4.7)%]、CD4/CD8(1.1±0.2)수평현저고우B조(P＜0.05혹＜0.01);화료기간A조구토발생솔(4.9%,2/41)현저저우B조(26.8%,11/41),평균매일섭입량[(1312±114)ml]현저다우B조[(765±186)ml](P＜0.05).연기류치공장조구관미발생상관엄중병발증.결론 연기류치공장조구관간단장내영양재진전기위암술후보조화료중응용시안전가행적,가이유효지제고술후보조화료환자적영양급면역상황.
Objegtive To study the feasibility and clinical effects of enteral nutrition by needle catheter jejunostomy(NCJ)tube in the postoperative adjuvant chemotherapy for patients of staged gastric cancer.Methods Eighty-two patients with staged gastric cancer underwent radical gastrectomy and going to receive chemotherapy were randomly divided into group A(41 cases)and group B(41 cases).All of the patients had been NCJ.Group A received enteral nutrition through the tube during chemotherapy,and group B had been given general diet.A series of parameters were measured post-chemotherapy.And the gastrointestinal complications were carefully observed.Results In post-chemotherapy,the level of hemoglobin,albumin,prealbumin,interleukin-2,natural killer cell activities and CD3+,CDd4+,CD4/CD8 in group A[(106.9±12.0)g/L,(26.2±1.4)g/L,(202.9±32.2)mg/L,(11.9±2.1)μg/L,(21.3±5.2)%,(62.9±3.3)%,(26.1±4.7)%,1.1±0.2]were significantly higher than those in group B(P＜0.05 or＜0.01).The incidences of vomiting in group A(4.9%,2/41)was significantly lower than that in group B (26.8%,11/41)(P＜0.05).The average intake in group A[(1312±114)ml]was significantly more than that in group B[(76.5±186)ml](P＜0.05).No severe enteral nutrition related complications occurred in group A.Conclusions It is safe and feasible to enteral nutrition supported by NCJ tube in chemotherapy for patients of staged gastric cancer.It can improve the nutrition status and immune function in the given patients.
