CAJ | 학술논문

目的探讨血清神经元特异性烯醇化酶(NSE)和高敏C反应蛋白(hs-CRP)对新生儿缺氧缺血性脑病(HIE)患儿病情和预后的评估价值.方法测定40例HIE患儿(HIE组)的急性期及恢复期和20例健康新生儿(对照组)血清NSE、hs-CRP水平,并分析HIE组急性期NSE、hs-CRP水平与临床分度之间的关系.结果 HIE组急性期血清NSE、hs-CRP水平[(32.88±12.61)μg/L、(6.43±2.07)mg/L]明显高于对照组[(8.62±3.58)μg/L、(2.61±0.95)mg/L](P＜0.01).HIE组重度患儿血清NSE、hs-CRP水平显著高于中、轻度患儿(P＜0.01).病情越重,血清NSE、hs-CRP水平越高.结论血清NSE、hs-CRP水平是反映脑内神经元损伤或坏死的客观指标,可作为早期判断HIE病情及预后的客观指标.
목적 탐토혈청신경원특이성희순화매(NSE)화고민C반응단백(hs-CRP)대신생인결양결혈성뇌병(HIE)환인병정화예후적평고개치.방법 측정40례HIE환인(HIE조)적급성기급회복기화20례건강신생인(대조조)혈청NSE、hs-CRP수평,병분석HIE조급성기NSE、hs-CRP수평여림상분도지간적관계.결과 HIE조급성기혈청NSE、hs-CRP수평[(32.88±12.61)μg/L、(6.43±2.07)mg/L]명현고우대조조[(8.62±3.58)μg/L、(2.61±0.95)mg/L](P＜0.01).HIE조중도환인혈청NSE、hs-CRP수평현저고우중、경도환인(P＜0.01).병정월중,혈청NSE、hs-CRP수평월고.결론 혈청NSE、hs-CRP수평시반영뇌내신경원손상혹배사적객관지표,가작위조기판단HIE병정급예후적객관지표.
Objective To investigate the serum neuron-specific enolase (NSE) and high sensitivity C-reactive protein (hs-CRP) on neonatal hypoxic-ischemic encephalopathy (HIE) in children with illness and prognosis of assessed value. Method The serum NSE, hs-CRP levels of 40 patients with HIE (HIE group) of the acute stage and convalescence, and 20 healthy neonates (control group ) were measured and the clinical sub-degree relationships were analyzed. Results The serum NSE, hs-CRP levels in HIE group of the acute stage [ (32.88 ± 12.61 ) μ g/L, (6.43 ± 2.07) mg/L] were significantly higher than those in control group [(8.62 ± 3.58) μ g/L, (2.61 ± 0.95) mg/L](P ＜ 0.01 ). The serum NSE, hs-CRP levels in HIE group of the severe acute stage were significantly higher than those of the mild and light acute stage (P＜0.01 ). The more severe disease, the more higher NSE, hs-CRP. Conclusion The serum NSE, hs-CRP reflect the brain neuronal damage or necrosis of the objective indicators that could be used as early objective indicators to judge the pathogenetic condition and prognosis of HIE.