CAJ | 학술논문

目的探讨18FDG PET-CT在诊断兔鼻咽肿瘤颈部淋巴结性质上的作用.方法建立兔鼻咽VX2肿瘤模型,对颈部淋巴结行PET-CT诊断并用病理诊断证实,同时与MRI诊断相比较.结果 30只鼻咽VX2肿瘤兔解剖检出颈部淋巴结共53个,病理证实转移淋巴结42个,且淋巴结是否转移与淋巴结体积、最短径显著相关(r=9.18,P=0.007;r=2.77,P:0.008).体积>0.5 cm3(25个)、≤0.5 cm3(17个)淋巴结的PET-T诊断敏感性分别为96%(24个)、29%(5个),最短径≥0.5cm(30个)、<0.5 cm(12个)淋巴结的PET-CT诊断敏感性分别为83%(25个)、33%(4个),PET-CT诊断的总敏感性为69%(29/42),特异性为100%(11/11),准确性为95%(40/42).MRI诊断敏感性为60%(25/42),特异性为9l%(10/11),准确性为83%(35/42).PET-CT图像所测淋巴结体积与实测体积相当(t=-1.23,P=0.233),MRI的则大于实测体积(t=-3.99,P=0.001).结论 18FDGPET-CT诊断颈部淋巴结转移的敏感性、特异性均高于MRI,特别对体积>0.5 cm3或最短径≥0.5 cm的颈部淋巴结转移的敏感性更高,对更小淋巴结的诊断仍有参考价值,仉假阴性较高.
목적 탐토18FDG PET-CT재진단토비인종류경부림파결성질상적작용.방법 건립토비인VX2종류모형,대경부림파결행PET-CT진단병용병리진단증실,동시여MRI진단상비교.결과 30지비인VX2종류토해부검출경부림파결공53개,병리증실전이림파결42개,차림파결시부전이여림파결체적、최단경현저상관(r=9.18,P=0.007;r=2.77,P:0.008).체적>0.5 cm3(25개)、≤0.5 cm3(17개)림파결적PET-T진단민감성분별위96%(24개)、29%(5개),최단경≥0.5cm(30개)、<0.5 cm(12개)림파결적PET-CT진단민감성분별위83%(25개)、33%(4개),PET-CT진단적총민감성위69%(29/42),특이성위100%(11/11),준학성위95%(40/42).MRI진단민감성위60%(25/42),특이성위9l%(10/11),준학성위83%(35/42).PET-CT도상소측림파결체적여실측체적상당(t=-1.23,P=0.233),MRI적칙대우실측체적(t=-3.99,P=0.001).결론 18FDGPET-CT진단경부림파결전이적민감성、특이성균고우MRI,특별대체적>0.5 cm3혹최단경≥0.5 cm적경부림파결전이적민감성경고,대경소림파결적진단잉유삼고개치,장가음성교고.
Objective To study 18F-deoxyglueose positron emission tomography computed tomo graphy(18 FDG PET-CT) in the diagnosis of cervical lymph node(LN) metastasis from rabbit nasopharyngeal VX2 carcinoma.Methods Nasopharyngeal VX2 carcinoma model using 30 rabbits was established. 18 FDG PET-CT,MRI and pathological diagnosis were performed and compared.ResultsFifty-three cervi cal LNs were picked up from resected specimens of 30 rabbits with nasopharyngeal VX2 carcinoma.There were 42 pathologically confirmed positive LNs.Positivity rate was significantly correlated with the volume and the shortest diameter of the LNs (r = 9.18,P =0.007 ; r = 2.77,P = 0.008).The diagnostic sensitivity of PET-CT was 96% (24/25) and 29% (5/17) for LNs with volume >0.5 cm3 and ≤0.5 cm3 ,83% (25/30) and 33% (4/12) for LNs with the shortest diameter ≥0.5 cm and < 0.5 cm,respectively.The diagnostic sensitivity,specificity and accuracy of PET-CT was 69% (29/42) ,100% (11/11) and 95% (40/42) ,com paring with 60% (25/42) ,91% (10/11) and 83% (35/42) of MRl,respectively.The volume measured by PET-CT images was not significantly different from the pathologically measured volume (t =-1.23,P = 0.233) ,while the volume measured by MRI was significantly different from the pathologically measured vol ume (t =-3.99,P = 0.001).Conclusions The sensitivity,specificity and accuracy of PET-CT are better than those of MRl,especially for the cervical lymph nodes with volume >0.5 cm3 or the shortest diameter ≤ 0.5 cm.PET-CT also can be used to detect the smaller metastatic lymph nodes,though the false negative rate is higher.