输血感染艾滋病病毒1型母婴传播概率回顾性定群研究
수혈감염애자병병독1형모영전파개솔회고성정군연구
Retrospective cohort study on the rate of mother-to-child transmission among mothers infected with human immunodeficiency virus type 1 through blood transfusion
  • 万方数据
    中华流行病学杂志 중화류행병학잡지
    CHINESE JOURNAL OF EPIDEMIOLOGY
    2009年 6期 564-566 ,共3页

    陈素良%赵宏儒%李晓梅%张玉琪%靳广生%赵翠英%张延平%白广义%李保军%梁良%陈志强%回延良%刘福宝%徐智贤%朱建国%毛宇嵘

    진소량%조굉유%리효매%장옥기%근엄생%조취영%장연평%백엄의%리보군%량량%진지강%회연량%류복보%서지현%주건국%모우영

    人免疫缺陷病毒%母婴传播%概率%回顾性定群研究 人免疫缺陷病毒%母嬰傳播%概率%迴顧性定群研究
    인면역결함병독%모영전파%개솔%회고성정군연구
    Human immunodeficiency virus%Mother-to-child transmission%Probability%Retrospective cohort study
    目的 研究HIV-1型母婴传播率.方法 对某市8个乡全部居民普查出的63例一次性输血感染HIV的母亲及其子女进行研究,调查母亲的受血时间、子女的出生时间、出生方式、母乳喂养等情况.母亲输血感染HIV的84名子女作为母婴传播的观察对象,采集的血清标本用ELISA法进行HIV抗体初筛,用Western-blot法进行确证.结果 存在母婴传播危险因素的子女母婴感染率为32.1%(27/84).存在宫内、分娩、母乳3个因素和存在分娩、母乳2个因素的感染率分别为36.8%(7/19)和35.7%(5/14),存在宫内、分娩2个因素的感染率为14.3%(2/14);单纯母乳喂养感染率为37.9%(11/29).经合并分析,存在母乳喂养因素的母婴传播组HIV-1感染率(36.9%,24/65)显著高于人工喂养的母婴传播组(11.8%,2/17).结论 一次性输血感染HIV的母亲,母婴感染率因传播危险因素不同而有所不同,母乳喂养在母婴传播HIV中具有重要作用.
    목적 연구HIV-1형모영전파솔.방법 대모시8개향전부거민보사출적63례일차성수혈감염HIV적모친급기자녀진행연구,조사모친적수혈시간、자녀적출생시간、출생방식、모유위양등정황.모친수혈감염HIV적84명자녀작위모영전파적관찰대상,채집적혈청표본용ELISA법진행HIV항체초사,용Western-blot법진행학증.결과 존재모영전파위험인소적자녀모영감염솔위32.1%(27/84).존재궁내、분면、모유3개인소화존재분면、모유2개인소적감염솔분별위36.8%(7/19)화35.7%(5/14),존재궁내、분면2개인소적감염솔위14.3%(2/14);단순모유위양감염솔위37.9%(11/29).경합병분석,존재모유위양인소적모영전파조HIV-1감염솔(36.9%,24/65)현저고우인공위양적모영전파조(11.8%,2/17).결론 일차성수혈감염HIV적모친,모영감염솔인전파위험인소불동이유소불동,모유위양재모영전파HIV중구유중요작용.
    Objective To study the rate of mother-to-child transmission (MTCT) on HIV-1. Methods All local residents from 8 townships in a region were screened for mothers who had a history of only one blood transfusion and 63 were found HIV-1 positive. A further study on these HIV-1 positive mothers and their children was conducted with the emphasis on the date of receiving blood transfusion, date and type of nationality, history regarding breastfeeding and so on. Sera specimens from 84 children born from 63 HIV-1 positive mothers were screened, using ELISA for HIV-1 antibody, and positive specimens were confirmed by Western-blot. Results The rate of MTCT was 32.1% (27/84) for children with all risk factors related to MTCT. Another 36.8% (7/19) were related to factors on intrauterine, intrapartum and breastfeeding, 35.7% (5/14) to intrapartum and breastfeeding factors, 14.3% (2/14) to intrauterine and intrapartum factors, 37.9% (11/29) to breastfeeding factor alone. By group combination analysis, the MTCT rate was 36.9% (24/65) with breastfeeding, 11.8% (2/17) with artificial feeding, and the former was significantly higher than the latter. Conclusion HIV-1 MTCT rate among mothers caused by a single blood transfusion varied with different risk factors. Breastfeeding played an important role in MTCT, appeared in our study.
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