中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2010年
6期
445-447
,共3页
受体,IgG%麻疹病毒%肺炎,细菌性%流式细胞术
受體,IgG%痳疹病毒%肺炎,細菌性%流式細胞術
수체,IgG%마진병독%폐염,세균성%류식세포술
Receptors,IgG%Measles%Pneumonia,bacterial%Flow cytometry
目的 探讨中性粒细胞CD64的表达在麻疹并发细菌性肺炎患者的临床价值.方法 选取成人麻疹肺炎患者106例,按临床表现和细菌学检测结果 分为麻疹合并细菌性肺炎组及麻疹合并病毒肺炎组,应用流式细胞术测定中性粒细胞CD64,同时测外周血C反应蛋白(CRP)和白细胞.结果 麻疹合并细菌性肺炎组出疹期CD64水平为(32.15±11.07)MFI,明显高于恢复期(10.6±3.23)MFI(P＜0.01)和麻疹合并病毒性肺炎组(9.55±3.48)MFI(P＜0.01),以CD64≥8.50MFI、CRP≥10.00 mg/L、WBC≥9.05×109/L阳性标准,三种指标的敏感度分别为78.12%、80.48%、59.37%,特异度分别为76.19、67.67%、64.28%,准确度为77.35%、74.52%、61.32%;CD64与CRP呈正相关.结论 与CRP比较,中性粒细胞CD64的表达可作为麻疹合并细菌性肺炎患者的早期诊断、并可用于判断病情程度的可靠指标之一.
目的 探討中性粒細胞CD64的錶達在痳疹併髮細菌性肺炎患者的臨床價值.方法 選取成人痳疹肺炎患者106例,按臨床錶現和細菌學檢測結果 分為痳疹閤併細菌性肺炎組及痳疹閤併病毒肺炎組,應用流式細胞術測定中性粒細胞CD64,同時測外週血C反應蛋白(CRP)和白細胞.結果 痳疹閤併細菌性肺炎組齣疹期CD64水平為(32.15±11.07)MFI,明顯高于恢複期(10.6±3.23)MFI(P＜0.01)和痳疹閤併病毒性肺炎組(9.55±3.48)MFI(P＜0.01),以CD64≥8.50MFI、CRP≥10.00 mg/L、WBC≥9.05×109/L暘性標準,三種指標的敏感度分彆為78.12%、80.48%、59.37%,特異度分彆為76.19、67.67%、64.28%,準確度為77.35%、74.52%、61.32%;CD64與CRP呈正相關.結論 與CRP比較,中性粒細胞CD64的錶達可作為痳疹閤併細菌性肺炎患者的早期診斷、併可用于判斷病情程度的可靠指標之一.
목적 탐토중성립세포CD64적표체재마진병발세균성폐염환자적림상개치.방법 선취성인마진폐염환자106례,안림상표현화세균학검측결과 분위마진합병세균성폐염조급마진합병병독폐염조,응용류식세포술측정중성립세포CD64,동시측외주혈C반응단백(CRP)화백세포.결과 마진합병세균성폐염조출진기CD64수평위(32.15±11.07)MFI,명현고우회복기(10.6±3.23)MFI(P＜0.01)화마진합병병독성폐염조(9.55±3.48)MFI(P＜0.01),이CD64≥8.50MFI、CRP≥10.00 mg/L、WBC≥9.05×109/L양성표준,삼충지표적민감도분별위78.12%、80.48%、59.37%,특이도분별위76.19、67.67%、64.28%,준학도위77.35%、74.52%、61.32%;CD64여CRP정정상관.결론 여CRP비교,중성립세포CD64적표체가작위마진합병세균성폐염환자적조기진단、병가용우판단병정정도적가고지표지일.
Objective To study the clinical value of expression of peripheral blood neutrophil CD64 in adults with measles complicating pneumonia. Methods 106 patients were divided into two groups by clinical manifestation and bacteria study: measles complicating bacterial pneumonia group and measles complicating viral pneumonia, using flow cytometry determination of CD64, C-reactive protein (CRP) and white blood cell(WBC) count. Results The expression of CD64 in the bacterial pneumonia group with eruptive stage was (32. 15 ± 11.07)MFI, which was significantly higher than that in the group of with recovery stage( 10. 6 ± 3.23) MFI( P ＜ 0. 01 ) and viral pneumonia ( 9. 55 ± 3.48 ) MFI ( P ＜ 0. 01 ). These markers were considered positive if CD64 ≥ 8.5MFI、 CRP ≥ 10 mg/L and WBC ≥ 9.05 × 109/L. Their sensitivity was 78.12% ,80.48% and 59. 37%. Their specificity was 76. 19% ,67.67% and 64. 28%. Their accuracy rate was 77.35% ,74. 52% ,61.32% ;CD64 has a positive relationship with CRP. Conclusion Compared to CRP, expression of peripheral blood neutrophil CD64 can be a better marker in the early diagnosis of patients with measles complicating bacterial pneumonia and as one of the indicators of disease conditions.
