中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
15期
34-36
,共3页
高血压%醛固酮%心力衰竭%舒张性
高血壓%醛固酮%心力衰竭%舒張性
고혈압%철고동%심력쇠갈%서장성
Hypertension%Aldosterone%Heart failure%Diastolic
目的 观察醛固酮拮抗剂(螺内酯)对高血压病合并左心室舒张功能不全的影响.方法 选择高血压病合并左心室舒张功能不全患者共72例,随机分为常规治疗组(38例)和螺内酯组(34例).两组患者均按常规综合治疗,而螺内酯组在此基础上加用螺内酯片治疗.治疗前后观察患者血压、心率的变化,以彩色多普勒超声仪检测E峰(EV)、A峰(AV)、舒张期左房内径(LADd)、舒张期左室内径(LVDd)、左室射血分数(LVEF)等指标.结果 治疗前、后两组平均收缩压、平均舒张压、平均心率比较差异无统计学意义(P＞0.05),LADd、LVDd、LVEF等指标差异也无统计学意义(P＞0.05);但螺内酯组EV值明显高于常规治疗组(P＜0.05),AV值显著低于常规治疗组(P＜0.05),同时螺内酯组E/A值显著高于常规治疗组(P＜0.05).结论 螺内酯能显著改善高血压病合并左室舒张功能不全患者的心舒张功能,而且独立于降压以外.
目的 觀察醛固酮拮抗劑(螺內酯)對高血壓病閤併左心室舒張功能不全的影響.方法 選擇高血壓病閤併左心室舒張功能不全患者共72例,隨機分為常規治療組(38例)和螺內酯組(34例).兩組患者均按常規綜閤治療,而螺內酯組在此基礎上加用螺內酯片治療.治療前後觀察患者血壓、心率的變化,以綵色多普勒超聲儀檢測E峰(EV)、A峰(AV)、舒張期左房內徑(LADd)、舒張期左室內徑(LVDd)、左室射血分數(LVEF)等指標.結果 治療前、後兩組平均收縮壓、平均舒張壓、平均心率比較差異無統計學意義(P＞0.05),LADd、LVDd、LVEF等指標差異也無統計學意義(P＞0.05);但螺內酯組EV值明顯高于常規治療組(P＜0.05),AV值顯著低于常規治療組(P＜0.05),同時螺內酯組E/A值顯著高于常規治療組(P＜0.05).結論 螺內酯能顯著改善高血壓病閤併左室舒張功能不全患者的心舒張功能,而且獨立于降壓以外.
목적 관찰철고동길항제(라내지)대고혈압병합병좌심실서장공능불전적영향.방법 선택고혈압병합병좌심실서장공능불전환자공72례,수궤분위상규치료조(38례)화라내지조(34례).량조환자균안상규종합치료,이라내지조재차기출상가용라내지편치료.치료전후관찰환자혈압、심솔적변화,이채색다보륵초성의검측E봉(EV)、A봉(AV)、서장기좌방내경(LADd)、서장기좌실내경(LVDd)、좌실사혈분수(LVEF)등지표.결과 치료전、후량조평균수축압、평균서장압、평균심솔비교차이무통계학의의(P＞0.05),LADd、LVDd、LVEF등지표차이야무통계학의의(P＞0.05);단라내지조EV치명현고우상규치료조(P＜0.05),AV치현저저우상규치료조(P＜0.05),동시라내지조E/A치현저고우상규치료조(P＜0.05).결론 라내지능현저개선고혈압병합병좌실서장공능불전환자적심서장공능,이차독립우강압이외.
Objective To investigate the effect of aldosterone antagonists (spironolactone) on cardiac diastolic function in patients with hypertension complicated with left ventricular diastolic dysfunction.Methods A total of 72 patients with hypertension complicated with left ventricular diastolic dysfunction were involved in the study.They were randomly divided into routine treatment group(n =38)and spironolactone group(n =34).Both groups were given routine treatment and spironolactone group were given spironolactone additionally.Before and after treatment,the blood pressure,heart rate were monitored; the E peak (EV)and A peak(AV) were detected by color Doppler echocardiography,and left atrial diastolic dimension (LADd),left ventricular diastolic dimension (LVDd) and left ventricular ejection fraction (LVEF) were detected by echocardiography in all patients.Results Before and after treatment,the mean blood pressure,heart rate,LADd,LVDd and LVEF of the two groups showed no significant difference (P ＞ 0.05).After treatment,EV value of spironolactone group was significantly higher than that of control group (P ＜ 0.05),and E/A value was significantly higher than that of control group (P ＜0.05).Conclusions Spironolactone can significantly improve the heart diastolic function in patients with hypertension complicated with left ventricular diastolic dysfunction,and it doesn't depend on lowing blood pressure.
