CAJ | 학술논문

目的探讨胃动素(MOT)及血管活性肠肽(VIP)与胆囊结石形成的关系。方法收集48例胆囊结石患者术前及术后1、3、7天血浆和胆囊组织、胆汁，采用放射免疫法测定其MOT和VIP含量。结果胆囊结石患者术前及术后血浆MOT水平明显升高；胆囊组织及胆汁中MOT、VIP水平均明显升高，且胆囊组织中MOT与VIP呈明显正相关。结论 MOT和VIP可能通过改变胆囊的运动而促进了胆囊结石的形成。
목적탐토위동소(MOT)급혈관활성장태(VIP)여담낭결석형성적관계。방법수집48례담낭결석환자술전급술후1、3、7천혈장화담낭조직、담즙，채용방사면역법측정기MOT화VIP함량。결과담낭결석환자술전급술후혈장MOT수평명현승고；담낭조직급담즙중MOT、VIP수평균명현승고，차담낭조직중MOT여VIP정명현정상관。결론 MOT화VIP가능통과개변담낭적운동이촉진료담낭결석적형성。
Objective　To discuss the relationship between motilin, vasoactive intestinal peptide and the gallstone formation. Methods　The level of motilin, vasoactive intestinal peptide in plasma, bile and gallbladder tissue of 48 cases of chololithiasis before operation and the first, third, seventh day after cholecystectomy were mesured by radioimmunoassay. Results　The level of motilin in plasma was markedly increased in patients with chololithiasis before cholecystectomy and the first day after cholecystectomy. The level of motilin, vasoactive intestinal peptide in bile and gallbladder tissue were significantly increased in patients and motilin was positively correlated with vasoactive intestinal peptide in the gallbladder tissue. Conclusion　Motilin, vasoactive intestinal peptide might affect the gallstone formation by affecting the motility of gallbladder.