CAJ | 학술논문

目的观察辛伐他汀对不稳定型心绞痛(UAP)患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、纤维蛋白原(FIB)等的影响.方法选择UAP患者60例,随机分为辛伐他汀组和对照组,每组30例.对照组常规给药,辛伐他汀组在此基础上加服辛伐他汀20 mg,每晚1次,疗程8周.结果治疗后辛伐他汀组血清中CRP、IL-6、FIB浓度明显降低,和对照组相比P＜0.05,有显著性差异,并且与降脂作用无关.结论辛伐他汀除降脂作用外,具有抗炎、抗血栓形成作用.
목적관찰신벌타정대불은정형심교통(UAP)환자혈청C반응단백(CRP)、백세포개소-6(IL-6)、섬유단백원(FIB)등적영향.방법선택UAP환자60례,수궤분위신벌타정조화대조조,매조30례.대조조상규급약,신벌타정조재차기출상가복신벌타정20 mg,매만1차,료정8주.결과치료후신벌타정조혈청중CRP、IL-6、FIB농도명현강저,화대조조상비P＜0.05,유현저성차이,병차여강지작용무관.결론신벌타정제강지작용외,구유항염、항혈전형성작용.
[Objective] To investigate the effects of simvastatin to the levels of C-reaction protein (CRP) and in-terleukin-6(IL-6) and fibrinogen in serum of unstable angina pectoris (UAP) patients. [Methods] 60 UAP inpatientswere randomized. The cases were randomly divided into two groups, simvastatin group and control group. There were30 patients in each group. The patients of control group were administration routine. Besides the simvastatin grouptook 20 mg simvastatin every night for about 8 weeks. [Results] The concentrations of CRP, IL-6 and FIB de-creased obviously in serum of simvastatin group patients after administration. Compared with control group therewere significantly different (P＜.05). There were no correlations with blood lipid decrease by simvastatin. [Conclu-sion] In addition to decrease the concentration of blood lipid, simvastatins have the roles of anti-inflammation andanti-thrombosis. It points out that simvastatin may prevent and cure coronary heart disease (CHD).