CAJ | 학술논문

本研究通过调查中国南方SLE人群和健康对照人群中TNFR2基因两个位点(nt587,nt694)的多态性频率,探讨TNFR2基因多态性是否与中国汉族SLE人群的易感性相关.结果发现128例SLE中,nt587G的等位基因频率为54个(21.1%);而135例健康人群中nt587G的频率为35个(13.0%);SLE组明显高于健康对照人群(P＜0.05),携带nt587G的个体SLE发病危险性大.同时128例SLE中,nt694 A的等位基因频率为41个(16.0%);而健康人群中nt694 A的频率为32个(11.9%);两组比较无显著差异(P=0.149).提示TNFR2基因nt587的多态性与中国南方SLE人群相关,可能通过影响TNFR2的表达而参与SLE的发病,而nt694(G-A)的多态性与中国南方SLE人群不相关.
본연구통과조사중국남방SLE인군화건강대조인군중TNFR2기인량개위점(nt587,nt694)적다태성빈솔,탐토TNFR2기인다태성시부여중국한족SLE인군적역감성상관.결과발현128례SLE중,nt587G적등위기인빈솔위54개(21.1%);이135례건강인군중nt587G적빈솔위35개(13.0%);SLE조명현고우건강대조인군(P＜0.05),휴대nt587G적개체SLE발병위험성대.동시128례SLE중,nt694 A적등위기인빈솔위41개(16.0%);이건강인군중nt694 A적빈솔위32개(11.9%);량조비교무현저차이(P=0.149).제시TNFR2기인nt587적다태성여중국남방SLE인군상관,가능통과영향TNFR2적표체이삼여SLE적발병,이nt694(G-A)적다태성여중국남방SLE인군불상관.
In this paper, we designed to investigate the frequencies of tumor necrosis factor receptor 2 (TNFR2) polymorphisms at nt587 and nt694 in south Chinese SLE patients and healthy individuals and explore whether genetic variants in TNFR2 gene is involved in the pathogenesis of SLE. The results showed that the nt587G allele frequency was 21.1% in the 128 SLE patients and the allele frequency was 13.0% in the 135 healthy individuals, the former was significantly higher than the latter in the allele frequency (P ＜ 0.05). People with the nt587 G variant showed high risk to SLE. The frequency of nt694 was slightly but not statistically significantly increased in SLE patients compared with healthy controls(16.0% versus 11.9%, P= 0.149). These results indicate that the polymorphism at nt587 of TNFR2 is associated with the south Chinese SLE patients. The polymorphism at nt694 is not associated with SLE.