西安交通大学学报（医学版）
西安交通大學學報（醫學版）
서안교통대학학보（의학판）
JOURNAL OF XI'AN JIAOTONG UNIVERSITY(MEDICAL SCIENCES)
2009年
6期
729-731
,共3页
朱凤群%霍康%李春姬%狄鹏超
硃鳳群%霍康%李春姬%狄鵬超
주봉군%곽강%리춘희%적붕초
乙型肝炎病毒%基因型%微板核酸分子杂交%肝功能
乙型肝炎病毒%基因型%微闆覈痠分子雜交%肝功能
을형간염병독%기인형%미판핵산분자잡교%간공능
hepatitis B virus%genotype%microboard nucleate molecular hybridization%function of liver
目的 探讨乙型肝炎病毒基因型与肝功能的关系.方法 采用微板核酸分子杂交ELISA法检测93例不同临床类型的乙型肝炎患者的基因型并同时测定肝功能.结果 93例不同临床类型乙型病毒性肝炎患者中,B型24例(25.81%),C型59例(63.44%),D型5例(5.38%),混合型5例(B/D 3例,C/D 2例,占5.38%).93例不同临床类型的乙型肝炎患者中,以C基因型为主,其次为B基因型,部分以D型和混合型存在,无A、E、F型.按照慢性乙型肝炎、亚急性重型肝炎、肝硬化的顺序,C基因型的检出率逐渐增多,B基因型的检出率逐渐减少.肝癌患者C基因型的检出率没有依次增高.C基因型各型乙型肝炎患者的ALT、AST、TBIL均高于B型,ALB低于B型,但差别无统计学意义.结论 西安地区病毒性肝炎以C基因型为主,部分以B、D及混合型存在,未发现A、E、F型.除肝癌外,C型的检出率随临床类型的加重而增多.
目的 探討乙型肝炎病毒基因型與肝功能的關繫.方法 採用微闆覈痠分子雜交ELISA法檢測93例不同臨床類型的乙型肝炎患者的基因型併同時測定肝功能.結果 93例不同臨床類型乙型病毒性肝炎患者中,B型24例(25.81%),C型59例(63.44%),D型5例(5.38%),混閤型5例(B/D 3例,C/D 2例,佔5.38%).93例不同臨床類型的乙型肝炎患者中,以C基因型為主,其次為B基因型,部分以D型和混閤型存在,無A、E、F型.按照慢性乙型肝炎、亞急性重型肝炎、肝硬化的順序,C基因型的檢齣率逐漸增多,B基因型的檢齣率逐漸減少.肝癌患者C基因型的檢齣率沒有依次增高.C基因型各型乙型肝炎患者的ALT、AST、TBIL均高于B型,ALB低于B型,但差彆無統計學意義.結論 西安地區病毒性肝炎以C基因型為主,部分以B、D及混閤型存在,未髮現A、E、F型.除肝癌外,C型的檢齣率隨臨床類型的加重而增多.
목적 탐토을형간염병독기인형여간공능적관계.방법 채용미판핵산분자잡교ELISA법검측93례불동림상류형적을형간염환자적기인형병동시측정간공능.결과 93례불동림상류형을형병독성간염환자중,B형24례(25.81%),C형59례(63.44%),D형5례(5.38%),혼합형5례(B/D 3례,C/D 2례,점5.38%).93례불동림상류형적을형간염환자중,이C기인형위주,기차위B기인형,부분이D형화혼합형존재,무A、E、F형.안조만성을형간염、아급성중형간염、간경화적순서,C기인형적검출솔축점증다,B기인형적검출솔축점감소.간암환자C기인형적검출솔몰유의차증고.C기인형각형을형간염환자적ALT、AST、TBIL균고우B형,ALB저우B형,단차별무통계학의의.결론 서안지구병독성간염이C기인형위주,부분이B、D급혼합형존재,미발현A、E、F형.제간암외,C형적검출솔수림상류형적가중이증다.
Objective To investigate the relationship between hepatitis B virus (HBV) genotype and liver function. Methods The method of microboard nucleate molecular hybridization was employed to detect the genotype in 93 HBV patients of different clinical types and the function of liver. Results Among the 93 HBV patients of different clinical types, there were 24 cases of genotype B (25.81%), 59 cases of genotype C (63.44%), 5 cases of genotype D (5.38%), and 5 cases of mixed type (3 cases of B/D, 2 cases of C/D, 5.38%). Therefore, genotype C took up the largest proportion, followed by genotype B, and then D and mixed genotypes, but there was no genotype A, E or F. The detection rate of genotype C increased according to the sequence of chronic hepatitis B, subacute severe hepatitis and hepatocirrhosis while the detection rate of genotype B decreased gradually. However, the detection rate of genotype C in hepatocellar carcinoma did not rise correspondingly. The levels of ALT, AST and TBIL of genotype C were higher than those of genotype B, but the level of ALB in genotype C was lower than that of genotype B. None of the differences had significance. Conclusion Most of HBV genotypes in Xi'an were C, some of them were B, D and mixed genotypes, but no genotype A, E or F was detected. Except hepatocellar carcinoma, the detection rate of genotype C rose according to the severity of clinical type.
