CAJ | 학술논문

目的探讨功能性消化不良(FD)患儿的胃电图异常与胃排空的相关性.方法使用Polygraf ID 四导胃电分析系统和核素法固体胃排空测定51例FD患儿和25例健康体检儿童的胃电活动和胃排空情况.结果①FD组与对照组相比,正常慢波百分比(N%)明显低于对照组(P＜0.01);FD组患儿有较高的胃电异常发生率,主要表现为餐前餐后混合性胃电节律紊乱,共32例,占62.7%.②FD组与对照组相比,4个导联餐后/餐前功率比差异有统计学意义(P＜0.05),显示FD组餐后主功率不增加.③FD组患儿餐前主频不稳定系数,餐前与餐后主功率不稳定系数增高;FD组患儿餐前、餐后慢波耦联率(%)分别为26.95±13.69,26.93±12.63,对照组为69.02±5.15,70.18±4.68,FD组慢波耦联率低于对照组(P＜0.01).④FD组患儿胃排空延迟占23.5%,经Logistic多因素相关分析胃排空延迟与餐前、餐后慢波耦联率存在负相关(偏回归系数分别为-0.513,-0.296).结论 FD患儿有较高的胃电异常发生率,主要表现为胃电节律紊乱和餐后主功率不增加,餐前主频不稳定系数,餐前与餐后主功率不稳定系数增高,慢波耦联率降低;胃排空延迟与慢波耦联率存在负相关.提示胃电异常在FD的发病中有一定意义.
목적 탐토공능성소화불량(FD)환인적위전도이상여위배공적상관성.방법 사용Polygraf ID 사도위전분석계통화핵소법고체위배공측정51례FD환인화25례건강체검인동적위전활동화위배공정황.결과①FD조여대조조상비,정상만파백분비(N%)명현저우대조조(P＜0.01);FD조환인유교고적위전이상발생솔,주요표현위찬전찬후혼합성위전절률문란,공32례,점62.7%.②FD조여대조조상비,4개도련찬후/찬전공솔비차이유통계학의의(P＜0.05),현시FD조찬후주공솔불증가.③FD조환인찬전주빈불은정계수,찬전여찬후주공솔불은정계수증고;FD조환인찬전、찬후만파우련솔(%)분별위26.95±13.69,26.93±12.63,대조조위69.02±5.15,70.18±4.68,FD조만파우련솔저우대조조(P＜0.01).④FD조환인위배공연지점23.5%,경Logistic다인소상관분석위배공연지여찬전、찬후만파우련솔존재부상관(편회귀계수분별위-0.513,-0.296).결론 FD환인유교고적위전이상발생솔,주요표현위위전절률문란화찬후주공솔불증가,찬전주빈불은정계수,찬전여찬후주공솔불은정계수증고,만파우련솔강저;위배공연지여만파우련솔존재부상관.제시위전이상재FD적발병중유일정의의.
Objective To investigate the correlations between electrogastrogram(EGG) and gastric emptying(GE) in children with functional dyspepsia(FD).Methods A total of 51 children with FD and 25 healthy children as control were enrolled into this study.Polygraph ID 4-channel EGG analysis system was used for EGG recording and gastric emptying of solids was studied by using a standardized egg meal labeled with ~(99m)Technetium sulfur colloid for each subject.Results(1)Compared with the control group,the percentage of normal slow wave(N%) in the FD group was significantly lower than that of the control group(P＜0.01).Children with FD had higher rates of abnormal EGG,in which 32 cases showed mixed dysrhythmia preprandial and postprandial recordings(62.7%).(2)The two groups had significant difference in ratio of the percentage of preprandial dominant power(DP) to postprandial DP(P＜0.05),it showed that the postprandial DP of the FD group did not increase.(3)The postprandial dominant power instability coefficient(DPIC) as well as preprandial DPIC and dominant frequency instability coefficient (DFIC) in the FD group were increased.The coupling of the slow wave of preprandial and postprandial EGG in the FD group(26.95±13.69,26.93±12.63 respectively) significantly decreased as compared with those in the control group(69.02±5.15,70.18±4.68,P＜0.01).(4)The rate of delayed gastric emptying in the FD group was 23.5%.The results of multivariate Logistic regression analysis showed that there was a significant negative correlation between the delayed gastric emptying and the coupling of the slow wave(partial regression coefficient=-0.513,-0.296 respectively).Conclusions Patients with FD had more abnormal findings in EGG than the control group did,and there was a significant negative correlation between the delayed gastric emptying and the coupled response of the slow wave.The abnormal gastric electrical activity may have certain significance in pathogenesis of FD.