CAJ | 학술논문

目的探讨急性脑梗死患者血浆溶血磷脂酸(LPA)水平变化及其临床意义.方法应用有机溶剂抽提法对67例急性脑梗死患者(急性脑梗死组)动态检测血浆LPA含量,分析其与梗死部位(皮质支和深穿支)的关系,并与40例健康体检者(正常对照纽)进行对照.结果急性脑梗死组发病后6 h血浆LPA含量[(3.45±0.32)μmol/L]明显高于正常对照组[(2.63±0.31)μmol/L,P<0.01],并在发病后24 h达到高峰[(4.05±0.51)μmol/L],14 d接近正常,与高峰点比较差异有统计学意义(P<0.01);皮质支组发病后24 h血浆LPA水平[(4.64±0.55)μmol/L]高于深穿支组(P<0.01).结论急性脑梗死患者血浆LPA水平与病程、病灶部位有关.LPA在急性脑梗死发生时具有预警作用,对急性脑梗死的防治具有重要的临床意义.
목적 탐토급성뇌경사환자혈장용혈린지산(LPA)수평변화급기림상의의.방법 응용유궤용제추제법대67례급성뇌경사환자(급성뇌경사조)동태검측혈장LPA함량,분석기여경사부위(피질지화심천지)적관계,병여40례건강체검자(정상대조뉴)진행대조.결과 급성뇌경사조발병후6 h혈장LPA함량[(3.45±0.32)μmol/L]명현고우정상대조조[(2.63±0.31)μmol/L,P<0.01],병재발병후24 h체도고봉[(4.05±0.51)μmol/L],14 d접근정상,여고봉점비교차이유통계학의의(P<0.01);피질지조발병후24 h혈장LPA수평[(4.64±0.55)μmol/L]고우심천지조(P<0.01).결론 급성뇌경사환자혈장LPA수평여병정、병조부위유관.LPA재급성뇌경사발생시구유예경작용,대급성뇌경사적방치구유중요적림상의의.
Objective To investigate the changes and the significance of plasma lysophosphalidic acid (LPA) in patients with acute cerebral infarction(ACI). Methods The levels of plasma LPA were examined with organic solvent extraction in 67 cases of ACI and 40 cases of health examination (control group). The correlation between the levels of plasma LPA and the infarction sites was analyzed. Results The level of plasma LPA were higher in cases with ACI than those in healthy controls(P <0.01) and it reached the peak after 24 hours and went back to the normal level on the 14th day (P <0.01). The level of LPA in cortical branches was higher than that in deep branches(P <0.01). Conclusions The level of LPA in cases with ACI was related to the course of disease and the site of infarction. LPA showes the prewarning effect when the acute cerebral infarction occured. LPA has im-portant clinical significance of preventing and treating the acute cerebral infarction.