中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2009年
12期
1004-1007
,共4页
张冬红%周丽雅%林三仁%丁士刚%黄永辉%顾芳%张莉%李渊%崔荣丽%孟灵梅%闫秀娥%张静
張鼕紅%週麗雅%林三仁%丁士剛%黃永輝%顧芳%張莉%李淵%崔榮麗%孟靈梅%閆秀娥%張靜
장동홍%주려아%림삼인%정사강%황영휘%고방%장리%리연%최영려%맹령매%염수아%장정
螺杆菌%幽门%流行病学
螺桿菌%幽門%流行病學
라간균%유문%류행병학
Helicobacter pylori%Epidemiology
目的 探讨中国胃癌高发区山东牟平和低发区北京延庆儿童及成人幽门螺杆菌(H.pylori,Hp)感染现状及变化.方法 2006年5-7月检测两地区8～15岁儿童和40～79岁成人2065例.收集同地区90年代初资料及1991年和2006年于我院进行胃镜检查的所有病例11 656例,分析Hp感染率变化.结果 牟平儿童和成人Hp阳性率分别为37.69%和50.95%,显著高于延庆儿童和成人的25.58%和41.35%(P<0.01).与1991年相比,2006年牟平儿童Hp阳性率下降显著(P<0.001),而延庆儿章下降无统计学意义(P>0.05).两地区成人HP阳性率均显著下降(P<0.01).我院病例Hp感染率下降显著(P<0.001).结论 胃癌高发区儿童和成人Hp感染率显著高于胃癌低发区,Hp感染可能是胃癌发生的危险因素之一.近十多年来Hp感染率在中国人群中有下降趋势.
目的 探討中國胃癌高髮區山東牟平和低髮區北京延慶兒童及成人幽門螺桿菌(H.pylori,Hp)感染現狀及變化.方法 2006年5-7月檢測兩地區8～15歲兒童和40～79歲成人2065例.收集同地區90年代初資料及1991年和2006年于我院進行胃鏡檢查的所有病例11 656例,分析Hp感染率變化.結果 牟平兒童和成人Hp暘性率分彆為37.69%和50.95%,顯著高于延慶兒童和成人的25.58%和41.35%(P<0.01).與1991年相比,2006年牟平兒童Hp暘性率下降顯著(P<0.001),而延慶兒章下降無統計學意義(P>0.05).兩地區成人HP暘性率均顯著下降(P<0.01).我院病例Hp感染率下降顯著(P<0.001).結論 胃癌高髮區兒童和成人Hp感染率顯著高于胃癌低髮區,Hp感染可能是胃癌髮生的危險因素之一.近十多年來Hp感染率在中國人群中有下降趨勢.
목적 탐토중국위암고발구산동모평화저발구북경연경인동급성인유문라간균(H.pylori,Hp)감염현상급변화.방법 2006년5-7월검측량지구8～15세인동화40～79세성인2065례.수집동지구90년대초자료급1991년화2006년우아원진행위경검사적소유병례11 656례,분석Hp감염솔변화.결과 모평인동화성인Hp양성솔분별위37.69%화50.95%,현저고우연경인동화성인적25.58%화41.35%(P<0.01).여1991년상비,2006년모평인동Hp양성솔하강현저(P<0.001),이연경인장하강무통계학의의(P>0.05).량지구성인HP양성솔균현저하강(P<0.01).아원병례Hp감염솔하강현저(P<0.001).결론 위암고발구인동화성인Hp감염솔현저고우위암저발구,Hp감염가능시위암발생적위험인소지일.근십다년래Hp감염솔재중국인군중유하강추세.
Objectives To study the current prevalence and recent epidemiological changes of Helicobacter pylori (H. pylori) infection among children and adults residing in regions with high ( Muping, Shandong) and low (Yanqing, Beijing) incidence of gastric cancer in China. Methods A total of 2065 asymptomatic children aged 8-15 years and adults aged 40-79 years in the above two regions were examined from May to July 2006. The data obtained in early 1990s in the same two areas and those of 11 656 patients undergoing endoscopy in our hospital in 1991 and 2006 were also collected and studied. Results The prevalence ofH. pylori infection in Muping was significantly higher than that in Yanqing among both children (37.69% vs25.58%, P<0.001) and adults (50.95% vs41.35%, P < 0. 01 ). From 1991 to 2006 H. pylori prevalence among children aged 8-10 years decreased in Muping (60. 00% vs 32. 07% , P < 0.001), but not in Yanqing (24.06% vs 19.10%, P > 0. 05 ) . A significant decrease in H. pylori prevalence among adults in both regions was observed when the results of 2006 were compared with the data obtained in 1990 in Muping (50.95% vs 73.78% , P < 0. 001 ) and in 1992 inYanqing (41.35% vs 55. 35% , P < 0. 01 ) . The detected rate of H. pylori infection in patients undergoing endoscopy in our hospital decreased from 51. 88% in 1991 to 33. 59% in 2006 (P <0. 001). Conclusions The prevalence of H. pylori infection is significantly higher in areas with a high incidence of gastric cancer in China as compared with that in areas with a low incidence of gastric cancer among both children and adults. H. pylori infection may be a risk factor in gastric carcinogenesis. In the past decade or more, H.pylori infection rates have decreased in Chinese population.
