CAJ | 학술논문

现已证实,部分大肠肿瘤细胞及组织中胃泌素异常表达,胃泌素的异常表达与大肠肿瘤的发生、发展关系密切.胃泌素与受体结合后可通过一系列网络信号转导途径,使神经酰胺含量减少,促进肿瘤细胞的增生.阻断此途径,可能为大肠肿瘤的预防及治疗提供一个新的切人点.
현이증실,부분대장종류세포급조직중위비소이상표체,위비소적이상표체여대장종류적발생、발전관계밀절.위비소여수체결합후가통과일계렬망락신호전도도경,사신경선알함량감소,촉진종류세포적증생.조단차도경,가능위대장종류적예방급치료제공일개신적절인점.
It is confirmed that expression of gastrins in some colorectal neoplasms cells and their tissue is abnormal. The abnormal expression of gastrins have close relationship with the occurrence and the develop-ment of colorectal neoplasms. Gastrins binding with receptor can regulate ceramides content and promote cells proliferation by series of signal transduction pathways. Blocking these signal transduction pathways may provide a novel therapeutic approach for colorectal neoplasms prevention and treatment.