中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
10期
1201-1203
,共3页
高血压%高血压,肺性%心室功能障碍,左
高血壓%高血壓,肺性%心室功能障礙,左
고혈압%고혈압,폐성%심실공능장애,좌
Hypertension%Hypertension,pulmonary%Ventricular dysfunction,left
目的 通过对单纯性舒张功能障碍的高血压患者进行肺动脉高压流行性研究,分析单纯性舒张功能障碍的高血压患者发生肺动脉高压相关因素.方法 连续入选经超声心动图检查证实为单纯性舒张功能障碍的高血压患者800例,根据是否伴有肺动脉高压分为观察组(舒张功能障碍+肺动脉高压,161例)和对照组(舒张功能障碍,639例).所有患者使用经胸超声多普勒测量肺动脉收缩压、左心房和左心室内径及质量指数,左心室舒张功能检测指标包括二尖瓣口及二尖瓣环、肺静脉血流频谱检测结果.结果 观察组较对照组的年龄偏大,合并心房颤动偏多,组间差异均有统计学意义[年龄:(76±8)岁比(63±6)岁,心房颤动:26.7%(43/161)比5.8%(37/639),均P<0.01].观察组较对照组左心房内径更大、二尖瓣环舒张早期峰值流速更低,组间差异有统计学意义[左心房内径:(49±8)mm比(38±7)mm,二尖瓣环舒张早期峰值流速:(4.9±1.0)cm/s比(6.7±1.1)cm/s,均P<0.01].多因素回归分析显示年龄、心房颤动、二尖瓣环舒张早期峰值流速的相对危险度Exp(β)分别为1.168(95% CI:1.025~1.246)、2.235(95% CI:1.125 ~4.438)和0.386(95% CI:0.196 ~0.846),差异均有统计学意义(均P<0.05).结论 在单纯性舒张功能障碍的高血压患者肺动脉高压发生率较高,年龄、心房颤动、二尖瓣环舒张早期峰值流速是肺动脉高压的独立预测因素.
目的 通過對單純性舒張功能障礙的高血壓患者進行肺動脈高壓流行性研究,分析單純性舒張功能障礙的高血壓患者髮生肺動脈高壓相關因素.方法 連續入選經超聲心動圖檢查證實為單純性舒張功能障礙的高血壓患者800例,根據是否伴有肺動脈高壓分為觀察組(舒張功能障礙+肺動脈高壓,161例)和對照組(舒張功能障礙,639例).所有患者使用經胸超聲多普勒測量肺動脈收縮壓、左心房和左心室內徑及質量指數,左心室舒張功能檢測指標包括二尖瓣口及二尖瓣環、肺靜脈血流頻譜檢測結果.結果 觀察組較對照組的年齡偏大,閤併心房顫動偏多,組間差異均有統計學意義[年齡:(76±8)歲比(63±6)歲,心房顫動:26.7%(43/161)比5.8%(37/639),均P<0.01].觀察組較對照組左心房內徑更大、二尖瓣環舒張早期峰值流速更低,組間差異有統計學意義[左心房內徑:(49±8)mm比(38±7)mm,二尖瓣環舒張早期峰值流速:(4.9±1.0)cm/s比(6.7±1.1)cm/s,均P<0.01].多因素迴歸分析顯示年齡、心房顫動、二尖瓣環舒張早期峰值流速的相對危險度Exp(β)分彆為1.168(95% CI:1.025~1.246)、2.235(95% CI:1.125 ~4.438)和0.386(95% CI:0.196 ~0.846),差異均有統計學意義(均P<0.05).結論 在單純性舒張功能障礙的高血壓患者肺動脈高壓髮生率較高,年齡、心房顫動、二尖瓣環舒張早期峰值流速是肺動脈高壓的獨立預測因素.
목적 통과대단순성서장공능장애적고혈압환자진행폐동맥고압류행성연구,분석단순성서장공능장애적고혈압환자발생폐동맥고압상관인소.방법 련속입선경초성심동도검사증실위단순성서장공능장애적고혈압환자800례,근거시부반유폐동맥고압분위관찰조(서장공능장애+폐동맥고압,161례)화대조조(서장공능장애,639례).소유환자사용경흉초성다보륵측량폐동맥수축압、좌심방화좌심실내경급질량지수,좌심실서장공능검측지표포괄이첨판구급이첨판배、폐정맥혈류빈보검측결과.결과 관찰조교대조조적년령편대,합병심방전동편다,조간차이균유통계학의의[년령:(76±8)세비(63±6)세,심방전동:26.7%(43/161)비5.8%(37/639),균P<0.01].관찰조교대조조좌심방내경경대、이첨판배서장조기봉치류속경저,조간차이유통계학의의[좌심방내경:(49±8)mm비(38±7)mm,이첨판배서장조기봉치류속:(4.9±1.0)cm/s비(6.7±1.1)cm/s,균P<0.01].다인소회귀분석현시년령、심방전동、이첨판배서장조기봉치류속적상대위험도Exp(β)분별위1.168(95% CI:1.025~1.246)、2.235(95% CI:1.125 ~4.438)화0.386(95% CI:0.196 ~0.846),차이균유통계학의의(균P<0.05).결론 재단순성서장공능장애적고혈압환자폐동맥고압발생솔교고,년령、심방전동、이첨판배서장조기봉치류속시폐동맥고압적독립예측인소.
Objective To explore the prevalence of pulmonary hypertension in hypertensive patients with isolated diastolic heart failure,and to analyze the related clinical features.Methods We enrolled 800 consecutive hypertensive patients with isolated diastolic heart failure.All patients underwent transthoracic doppler echocardiography to measure the pulmonary artery systolic pressure,left atrial diameter and left ventricular mass index, diastolic function indices(including transmitral and mitral annular flow,pulmonary venous flow).We divided patients into two groups:one with diastolic heart failure and concomitant pulmonary hypertension,and one with diastolic heart failure but without concomitant pulmonary hypertension.Results Compared with control group of diastolic heart failure without concomitant pulmonary hypertension,patients with pulmonary hypertension were older[(76 ±8)years old vs(63 ± 6)years old,P < 0.01],more likely to have atrial fibrillation [26.7%(43/161)vs 5.8%(37/639),P < 0.01],larger left atrial diameter [(49 ± 8)mm vs(38 ± 7)mm,P < 0.01]and lower early mitral annular diastolic velocity [(4.9 ± 1.0)cm/s vs(6.7 ± 1.1)cm/s,P <0.01].Multivariate logistic regression analysis identified age,atrial fibrillation,early mitral annular diastolic velocity as the independent predictors of the presence of pulmonary hypertension.Conclusions Pulmonary hypertension is prevalent in hypertensive patients with diastolic heart failure.Age,atrial fibrillation,early mitral annular diastolic velocity are the independent predictors of the presence of pulmonary hypertension in this patient group.