CAJ | 학술논문

目的探讨北京市手足口病流行对急件弛缓性麻痹(AFP)发病的影响及其流行病学联系.方法分析2006-2008年北京市AFP发病情况.对AFP病例利用RD、L20B细胞分离及鉴定病毒,并对非脊髓灰质炎肠道病毒(NPEV)阳性标本进行肠道病毒71型(EV71)和柯萨奇病毒A16型(CoxA16)检测.通过国家法定传染病报告系统收集2008年北京市手足口病发病数据,并对北京市2008年AFP发病情况与手足口病流行特点进行比较和分析.结果 2006-2008年北京市AFP报告病例数从108例增加到177例,NPEV分离率从11.11%上升到20.34%,EV71和CoxA16两种病毒总检出率从0.93%上升到10.17%.结论 EV71和CoxA16可能是AFP发病增加的重要原因.这部分病例并不表现出疹等手足口病的典型症状,而是以AFP为惟一表现,尤其是在手足口病流行期,这部分病例所占比例更高.
목적 탐토북경시수족구병류행대급건이완성마비(AFP)발병적영향급기류행병학련계.방법 분석2006-2008년북경시AFP발병정황.대AFP병례이용RD、L20B세포분리급감정병독,병대비척수회질염장도병독(NPEV)양성표본진행장도병독71형(EV71)화가살기병독A16형(CoxA16)검측.통과국가법정전염병보고계통수집2008년북경시수족구병발병수거,병대북경시2008년AFP발병정황여수족구병류행특점진행비교화분석.결과 2006-2008년북경시AFP보고병례수종108례증가도177례,NPEV분리솔종11.11%상승도20.34%,EV71화CoxA16량충병독총검출솔종0.93%상승도10.17%.결론 EV71화CoxA16가능시AFP발병증가적중요원인.저부분병례병불표현출진등수족구병적전형증상,이시이AFP위유일표현,우기시재수족구병류행기,저부분병례소점비례경고.
Objective To study the prevalence of acute flaccid paralysis(AFP)and hand foot mouth disease(HFMD)in Beijing,from 2006-2008.Methods Data on AFP and HFMD was analyzed epidemiologically,during 2006-2008 in Beijing.All the specimens from AFP cases were isolated and identified by RD and L20B cell and all of non-polio enterovirus(NPEV)cases were assayed by HFMD real-time PCR kit.The relationship between AFP and HFMD was analyzed.Results During 2006-2008,the number of AFP case in Beijing increased from 108 to 177 while the NPEV isolation rate increased from 11.11%to 20.34%and the positive rate of enterovirus 71(EV71)and/or coxsackie virus A16(Cox A16)increased from 0.93%to 10.17%.Conclusion The prevalence of HFMD caused by EV71 and/or Cox A16 might have contributed to the increase of AFP cases in Beijing.