CAJ | 학술논문

目的探讨A型肉毒毒素(BTX-A)治疗脑卒中后肌痉挛的临床疗效.方法选择54例脑卒中后存在上肢肌肉痉挛的患者,按随机数字表法分为研究组和对照组(各27例),两组患者均进行肢体康复训练.研究组加行注射BTX-A.分别观察比较两组治疗后2周、4周、12周的Fugl-Meyer运动功能评测、改良 Ashworth肌痉挛量表评定情况及Barthel指数.结果治疗后2周、4周时,研究组与对照组的改良Ashworth评分评定比较差异具有统计学意义(P<0.01).治疗后4周、12周时,研究组与对照组的Fugl-Meycr评分变化、Barthel指数比较差异具有统计学意义(P<0.01).结论 BTX-A治疗脑卒中后上肢肌痉挛安全、简便、起效迅速,同时积极配合康复功能训缘,可以有效改善患者的运动功能和日常生活活动能力.
목적 탐토A형육독독소(BTX-A)치료뇌졸중후기경련적림상료효.방법 선택54례뇌졸중후존재상지기육경련적환자,안수궤수자표법분위연구조화대조조(각27례),량조환자균진행지체강복훈련.연구조가행주사BTX-A.분별관찰비교량조치료후2주、4주、12주적Fugl-Meyer운동공능평측、개량 Ashworth기경련량표평정정황급Barthel지수.결과 치료후2주、4주시,연구조여대조조적개량Ashworth평분평정비교차이구유통계학의의(P<0.01).치료후4주、12주시,연구조여대조조적Fugl-Meycr평분변화、Barthel지수비교차이구유통계학의의(P<0.01).결론 BTX-A치료뇌졸중후상지기경련안전、간편、기효신속,동시적겁배합강복공능훈연,가이유효개선환자적운동공능화일상생활활동능력.
Objective To observe the therapeutic effect ofbotulinum toxin type A (BTX-A) on spasticity of the upper extremity after stroke. Methods Fifty-four patients with upper extremity spasticity after stroke were randomly divided into treatment group and control group. The patients in treatment group were treated with BTX-A and rehabilitation training, while those in control group only with rehabilitation training. The efficacy was assessed with Modified Ashwonh Scale, Fugi-Meyer Assessment and Bartbel index before and 2, 4 and 12 weeks after treatment. Results The Ashworth scale score in treatment group was reduced significantly as compared with that in control group after 2- and 4-week treatment (P<0.01). And there was significant difference in FugI-Meyer Assessment and Barthel index between treatment group and control group after 4- and 12-week treatment (P<0.01). Conclusion The local injection of BTX-A for the muscle spasticity after stroke is effective and safe, and its combination with rehabilitation training can improve rapidly Fugl-Meyer scores and activities of daily living of patients.