CAJ | 학술논문

目的　研究原发性痛经的遗传易感性。方法　收集某纺织厂499名新婚女工的资料，采用Logistic回归分析，评价CYP1A1-HincⅡ和GSTT1多态性与重度原发性痛经的关系。结果　在未调整环境因素时CYP1A1-HincⅡ变异基因型虽对痛经有缓解趋势，但差异无显著性(CYP1A1-HincⅡ：OR＝0.64 95% CI：0.35～1.17)。而GSTT1变异基因型可增加重度原发性痛经危险性(GSTT1：OR＝1.83，95% CI：1.04～3.21)。调整潜在环境影响因素后，CY1A1-HincⅡ变异基因型显示对原发性痛经有缓解趋势(CYP1A1-HincⅡ：OR＝0.58，95% CI：0.31～1.08)，但差异仍无显著性。而GSTT1变异基因型仍显示可增加重度原发性痛经的危险性(GSTT1：OR＝2.01，95% CI：1.12～3.62)。结论　重度原发性痛经与GSTT1遗传多态性相关。
목적　연구원발성통경적유전역감성。방법　수집모방직엄499명신혼녀공적자료，채용Logistic회귀분석，평개CYP1A1-HincⅡ화GSTT1다태성여중도원발성통경적관계。결과　재미조정배경인소시CYP1A1-HincⅡ변이기인형수대통경유완해추세，단차이무현저성(CYP1A1-HincⅡ：OR＝0.64 95% CI：0.35～1.17)。이GSTT1변이기인형가증가중도원발성통경위험성(GSTT1：OR＝1.83，95% CI：1.04～3.21)。조정잠재배경영향인소후，CY1A1-HincⅡ변이기인형현시대원발성통경유완해추세(CYP1A1-HincⅡ：OR＝0.58，95% CI：0.31～1.08)，단차이잉무현저성。이GSTT1변이기인형잉현시가증가중도원발성통경적위험성(GSTT1：OR＝2.01，95% CI：1.12～3.62)。결론　중도원발성통경여GSTT1유전다태성상관。
Objective　To investigate the genetic susceptibility to primary dysmenorrhea.Methods　Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1-HincⅡ(CYP1A1-HincⅡ) and glutathion S-transferase-theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.Results　The result showed variant of CYP1A1-HincⅡ genotypes slightly reduced the risk of primary dysmenorrhea, but its OR value was not statistically significant (CYP1A1-HincⅡ:OR=0.64,95% CI 0.35-1.17).The GSTT1 genotype variant increased the risk of primary dysmenorrhea (GSTT1:OR=1.83,95% CI 1.04-3.21). After potential confounders were adjusted, the data showed that CYP1A1-HincⅡ variant had the trend of decreasing the risk of dysmenorrhea (CYP1A1-HincⅡ:OR=0.58,95% CI 0.31-1.08), but its decreasing scope was still not statistically significant. The GSTT1 variant genotypes showed a significantly increased risk of dysmenorrhea (GSTT1:OR=2.01, 95% CI 1.12-3.62).Conclusion　The results suggested that GSTT1 polymorphism be associated with heavy primary dysmenorrhea.