CAJ | 학술논문

目的探讨骨引导再生技术在上颌窦底提升中的成骨效果。方法对18只比格犬行双侧上颌窦底提升同期牙种植术。采用自身对照，左侧上颌窦行包绕式盖膜（实验侧），右侧行上颌窦颊侧开窗口盖膜（对照侧）。术后4、12、24周分别处死实验犬各6只，力学测试、大体标本及组织学观察。结果对照侧骨移植材料有移位，骨质吸收明显，种植体顶部暴露；实验侧种植体顶部骨移植材料无移位现象，有较厚的骨质覆盖。力学检测两组随时间的增加种植体被牵出的力增加；在24周时力学测试实验侧[(558.1±37.4)N]与对照侧[(471.4±31.5)N]比较，差异有统计学意义(P＜0.01)。组织学检查：双侧上颌窦底植入骨粉后均可见新生骨形成，随时间延长逐渐增多、成熟，骨粉颗粒逐渐减少。结论包绕式盖膜骨引导再生技术可减少上颌窦底提升后骨的吸收，促进种植体顶部骨形成。
목적탐토골인도재생기술재상합두저제승중적성골효과。방법대18지비격견행쌍측상합두저제승동기아충식술。채용자신대조，좌측상합두행포요식개막（실험측），우측행상합두협측개창구개막（대조측）。술후4、12、24주분별처사실험견각6지，역학측시、대체표본급조직학관찰。결과대조측골이식재료유이위，골질흡수명현，충식체정부폭로；실험측충식체정부골이식재료무이위현상，유교후적골질복개。역학검측량조수시간적증가충식체피견출적력증가；재24주시역학측시실험측[(558.1±37.4)N]여대조측[(471.4±31.5)N]비교，차이유통계학의의(P＜0.01)。조직학검사：쌍측상합두저식입골분후균가견신생골형성，수시간연장축점증다、성숙，골분과립축점감소。결론포요식개막골인도재생기술가감소상합두저제승후골적흡수，촉진충식체정부골형성。
Objective To investigate the effect of new bone formation in sinus augmentation with guided bone regeneration (GBR) using collagen membranes. Methods The first maxillary molars of 18 adult female Beagle dogs were extracted and the sinus floors of both sides were lifted with simultaneous implantation. A combination of autografts and Bio-Oss in a 2:1 ratio was placed in the space under the membrane. On the experimental side in each dog, the collagen membrane was folded at the lateral osteotomy window, the apex of the implants and a certain part of palatal bone. On the contralateral control side, the collagen membrane only covered the osteotomy window. Six animals were sacrificed at 4, 12, and 24 weeks respectively after surgery. Gross observation, biomechanical testing and histological examinations were performed. Results The translocation of grafted materials and bone absorption were found on the top of implants in the control side, and the grafted materials kept original shape at the experimental side at 4th week. The granule of Bio-oss absorbed obviously at 12th and 24th week. The pull-out force increased with time. At 24th week,the force of pull out was 558. 1 ±37.4 N at the study side,and 471.4 ±31.5 N at the control side. There was a significant difference in the pull-out force was noted between the two groups ( P ＜0. 01 ). Histological examination showed new bone formation on the sinus floor, and the grafted materials gradually reduced with time Conclusions GBR with the enfolded-coverage of the membrane can effectively decrease absorption of the grafted materialon the apical surface of implants and stimulate new bone formation in the sinus augmentation.