龙岩学院学报
龍巖學院學報
룡암학원학보
JOURNAL OF LONGYAN UNIVERSITY
2011年
5期
24-26
,共3页
药物分析%奥沙普秦%线性扫描极谱法%吸附波
藥物分析%奧沙普秦%線性掃描極譜法%吸附波
약물분석%오사보진%선성소묘겁보법%흡부파
pharmaceutical analysis%Oxaprozin%scanning polarographic%adsorptive wave
用线性扫描极谱法和循环伏安法研究奥沙普秦在0.05mol.L-1HAc-NaAc缓冲溶液（pH5.18）中的电化学行为。奥沙普秦于-1.221V（vs.SCE）处产生一灵敏的吸附波,奥沙普秦浓度在4.0μg.L-1～2000.0μg.L-1范围时,其一次微分线性扫描峰电流与奥沙普秦浓度呈良好的线性关系,相关系数r=0.99920（n=15）,检出限为2.4μg.L-1。对200.0μg.L-1奥沙普秦溶液进行6次平行试验,RSD为1.02%,回收率在94.3%～96.2%之间,方法可用于其在片剂中含量的测定。
用線性掃描極譜法和循環伏安法研究奧沙普秦在0.05mol.L-1HAc-NaAc緩遲溶液（pH5.18）中的電化學行為。奧沙普秦于-1.221V（vs.SCE）處產生一靈敏的吸附波,奧沙普秦濃度在4.0μg.L-1～2000.0μg.L-1範圍時,其一次微分線性掃描峰電流與奧沙普秦濃度呈良好的線性關繫,相關繫數r=0.99920（n=15）,檢齣限為2.4μg.L-1。對200.0μg.L-1奧沙普秦溶液進行6次平行試驗,RSD為1.02%,迴收率在94.3%～96.2%之間,方法可用于其在片劑中含量的測定。
용선성소묘겁보법화순배복안법연구오사보진재0.05mol.L-1HAc-NaAc완충용액（pH5.18）중적전화학행위。오사보진우-1.221V（vs.SCE）처산생일령민적흡부파,오사보진농도재4.0μg.L-1～2000.0μg.L-1범위시,기일차미분선성소묘봉전류여오사보진농도정량호적선성관계,상관계수r=0.99920（n=15）,검출한위2.4μg.L-1。대200.0μg.L-1오사보진용액진행6차평행시험,RSD위1.02%,회수솔재94.3%～96.2%지간,방법가용우기재편제중함량적측정。
The electrochemical behavior of Oxaprozin was studied by linear scanning polarographic and cyclic voltammograms method.In an acetate buffer solution of pH 5.18,a sensitive reductive wave of Oxaprozin appeared at 1.221V（vs.SCE）.The linear relationship between the peak current and the Oxaprozin concentration in the range of 4.0μg·L-1～2000.0μg·L-1（r=0.9992,n=15） was observed.The detection limit of the method was 2.8μg.L-1.RSD obtained from the data of 6 independent determinations at the concentration level of 200.0μg.L-1 was 1.02%,Recoveries obtained were in the range of 94.3%～96.2%.This method can be applied to the determination of Oxaprozin in tablets.
