CAJ | 학술논문

目的探讨丙烯腈(AN)对作业男工性激素水平的影响。方法选择71名长期接触AN的男工为接触组，选与其生活环境、经济条件、年龄相近的不接触任何毒物的男工50人为对照组，测定其血清中T、LH、FSH和E2水平。结果接触组血清中T水平明显下降而E2明显升高，与对照组比较差异均有非常显著性(P＜0.01)。结论 AN及其代谢产物CEO对睾丸组织的细胞产生了脂质过氧化作用致使间质细胞受损，因而使男工血中T下降、E2升高，其确切机制尚需深入研究。
목적탐토병희정(AN)대작업남공성격소수평적영향。방법선택71명장기접촉AN적남공위접촉조，선여기생활배경、경제조건、년령상근적불접촉임하독물적남공50인위대조조，측정기혈청중T、LH、FSH화E2수평。결과접촉조혈청중T수평명현하강이E2명현승고，여대조조비교차이균유비상현저성(P＜0.01)。결론 AN급기대사산물CEO대고환조직적세포산생료지질과양화작용치사간질세포수손，인이사남공혈중T하강、E2승고，기학절궤제상수심입연구。
Objective The effect of acrylonitrile(AN)exposure on m ale sexual hormone was investigated.Methods Blood samples of 71 mal e workers occupationally exposed to AN and 50 male workers without exposure hist ory were collected.The levels of serum testosterone(T),luteinizing hormone(LH),f ollicle stimulating hormone(FSH)and estradiol(E2)were determined by radioimmun oassay(RIA).Results The results showed that the level of T in expos ed workers was lower than that of unexposed workers,while the level of E2 was elevated significantly in exposed workers(P＜0.01).Conclu sions It was considered that AN exposure could induce lipid peroxidation and injure Leydigs cell in testis through AN and CEO,but the mechanism still needs further study.