CAJ | 학술논문

目的检测与分析nm23基因在胃癌组织中的表达，从而探讨其与胃癌生物学行为的关系。方法应用免疫组化技术检测80例胃癌切除标本nm23基因及PCNA蛋白表达，采用卡方检验进行统计学分析。结果nm23蛋白在胃癌组织中的阳性表达率为60%(48/80)，原发癌与转移癌组织中nm23蛋白表达无明显差异(P>0.05)，在低分化及伴有淋巴结转移胃癌中，nm23表达明显降低(P<0.05)。nm23蛋白表达与PCNA表达有关，差异有显著性意义(P<0.05)。结论nm23蛋白表达在胃癌淋巴结转移过程中发挥着重要作用，对评估胃癌生物学行为有一定意义，可能成为判断预后的肿瘤标志。
목적검측여분석nm23기인재위암조직중적표체，종이탐토기여위암생물학행위적관계。방법응용면역조화기술검측80례위암절제표본nm23기인급PCNA단백표체，채용잡방검험진행통계학분석。결과nm23단백재위암조직중적양성표체솔위60%(48/80)，원발암여전이암조직중nm23단백표체무명현차이(P>0.05)，재저분화급반유림파결전이위암중，nm23표체명현강저(P<0.05)。nm23단백표체여PCNA표체유관，차이유현저성의의(P<0.05)。결론nm23단백표체재위암림파결전이과정중발휘착중요작용，대평고위암생물학행위유일정의의，가능성위판단예후적종류표지。
Objective To determine and analyse the expression of nm23 gene intissues of gastric cancer and to evaluate it relation to the gastric cancer biological behavior.Methods The levels of nm23 gene and PCNA protein expresion were observed in 80 cases of gastric cancer using immunohistochemical techniqwe.Results The positive rate of nm23 gene expression was 60% in 80 cases of gastric cancer. No difference was observed between primary tumor lessions and metastasis tissue.The expression rate of nm23 protein was closely correlated to tumor differentiation and lymph mode metastasis (P<0.05).Also there is a negative correlation between nm23 and PCNA expreession.Conclusion nm23 protein detection could provide a molecular biological basis for the evaluation of patient's prognosis in gastric cancer.