CAJ | 학술논문

目的：研究慢性化脓中耳炎主要病原菌的种类及对抗生素的耐药情况。方法：对162例慢性化脓性中耳炎患者的耳分泌物进行细菌培养，对分离的病原菌进行药物敏感试验。结果：分离出病原菌183株，以金黄色葡萄球菌(63株)和铜绿假单胞菌(57株)为主，金黄色葡萄球菌对青霉素和红霉素的耐药性率分别为100％和71.4％，对氨基糖甙类、氟喹诺酮类和头孢类抗生素敏感性较高；铜绿假单胞茵对氨苄西林、头孢类抗生素耐药率较高，对氟喹诺酮类、氨基糖甙类抗生素敏感。结论：金黄色葡萄球菌和铜绿假单胞菌是济南地区慢性化脓性中耳炎的主要致病菌，二者对青霉素类抗生素有较高的耐药率。临床医师不能仅凭经验，而应根据细菌培养和药敏结果用药，以防耐药菌株产生。
목적：연구만성화농중이염주요병원균적충류급대항생소적내약정황。방법：대162례만성화농 성중이염환자적이분비물진행세균배양，대분리적병원균진행약물민감시험。결과：분리출병원균183주， 이금황색포도구균(63주)화동록가단포균(57주)위주，금황색포도구균대청매소화홍매소적내약성솔분별 위100％화71.4％，대안기당대류、불규낙동류화두포류항생소민감성교고；동록가단포인대안변서림、두포 류항생소내약솔교고，대불규낙동류、안기당대류항생소민감。결론：금황색포도구균화동록가단포균시제 남지구만성화농성중이염적주요치병균，이자대청매소류항생소유교고적내약솔。림상의사불능부빙경험， 이응근거세균배양화약민결과용약，이방내약균주산생。
Objective:To study pathogenic bacterium and its resistance to antibiotic of chronic suppurative otitis . Methods: Secretion from 162 cases of chronic suppurative otitis media were cultured. Drug- sensitive tests were done to separated pathogenic bacteria. Results: 183 strains pathogenic bacteria were isolated from middle ear secretion. The main pathogenic bacteria were staphylococcus aureus（ 63 strains ) and pseudomonas aeruginosa (57 strains ). Staphylococcus aurens had resistance rates of 100% and 71.4% to penicillin and erythromycin respectively. But it was sensitive to aminoglycoside antibiotics, cephalosporins and fluoroquinolones. Pseudomonas aeruginosa had a high resistence rate to ampicillin and staphylococcus, but it was more sensitive to fluoroquinolones and aminoglycoside antibiotics. Conclusion: Staphylococcus aureus and pseudomonas aeruginosa are main pathogenes of chronic suppurative otitis media in Jinan region. Both of them resisted high to penicillin antibiotics. So doctors should take program depending on the secretion culture and drug sensitive test.