临床军医杂志
臨床軍醫雜誌
림상군의잡지
CLINICAL JOURNAL OF MEDICAL OFFICER
2001年
1期
4-7
,共4页
周其全%陈玉魁%高丽菊%李宜成
週其全%陳玉魁%高麗菊%李宜成
주기전%진옥괴%고려국%리의성
失血性休克%免疫%氧合液%复苏
失血性休剋%免疫%氧閤液%複囌
실혈성휴극%면역%양합액%복소
目的 探讨脾脏在失血性伏克后的免疫调节作用。方法 取失血性休克犬进出脾脏的动静脉血及脾组织匀浆比浊法测定血浆及组织内IgA,IgM,IgG和补体C3，C4含量。结果 失血性休克后30min动脉血浆IgG有轻度降低，休克2h后IgG,IgM,IgA水平均明显降低。从脾静脉取血测定结果休克后30min各指标无显著变化，休克后2h休克组IgG水平降低，IgM和IgA水平轻度增高。脾组织匀浆测定结果是休克后2hIgG水平有明显增高，IgM和IgA水平有轻度降低，C3和C4水平增高。失血性休克经氧合液复苏后上述指标均有改善，IgG,IgM水平增高，C3，C4水平降低。结论 脾脏在抗体及补体的生成与释放上有重要调节功能，失血性休克可以降低其功能，改变体液免疫状态；而及时给以氧合高渗高胶液治疗可改善脾脏功能，纠正机体的体液免疫失衡，从而有利于休克的复苏。
目的 探討脾髒在失血性伏剋後的免疫調節作用。方法 取失血性休剋犬進齣脾髒的動靜脈血及脾組織勻漿比濁法測定血漿及組織內IgA,IgM,IgG和補體C3，C4含量。結果 失血性休剋後30min動脈血漿IgG有輕度降低，休剋2h後IgG,IgM,IgA水平均明顯降低。從脾靜脈取血測定結果休剋後30min各指標無顯著變化，休剋後2h休剋組IgG水平降低，IgM和IgA水平輕度增高。脾組織勻漿測定結果是休剋後2hIgG水平有明顯增高，IgM和IgA水平有輕度降低，C3和C4水平增高。失血性休剋經氧閤液複囌後上述指標均有改善，IgG,IgM水平增高，C3，C4水平降低。結論 脾髒在抗體及補體的生成與釋放上有重要調節功能，失血性休剋可以降低其功能，改變體液免疫狀態；而及時給以氧閤高滲高膠液治療可改善脾髒功能，糾正機體的體液免疫失衡，從而有利于休剋的複囌。
목적 탐토비장재실혈성복극후적면역조절작용。방법 취실혈성휴극견진출비장적동정맥혈급비조직균장비탁법측정혈장급조직내IgA,IgM,IgG화보체C3，C4함량。결과 실혈성휴극후30min동맥혈장IgG유경도강저，휴극2h후IgG,IgM,IgA수평균명현강저。종비정맥취혈측정결과휴극후30min각지표무현저변화，휴극후2h휴극조IgG수평강저，IgM화IgA수평경도증고。비조직균장측정결과시휴극후2hIgG수평유명현증고，IgM화IgA수평유경도강저，C3화C4수평증고。실혈성휴극경양합액복소후상술지표균유개선，IgG,IgM수평증고，C3，C4수평강저。결론 비장재항체급보체적생성여석방상유중요조절공능，실혈성휴극가이강저기공능，개변체액면역상태；이급시급이양합고삼고효액치료가개선비장공능，규정궤체적체액면역실형，종이유리우휴극적복소。
Objective To investigate the immunoregulatory effect of spleen inhemorrhagic shock. Methods The content of immunoglobulin A, G, M and complement 3, 4 in arterial and veinal blood of spleen and in spleen tissue were determined by radioimmunoassay. Results 30 mins after hemorrhagic shock, the IgG level in arterial plasma was moderately reduced, two hours after hemorrhagic shock, the level of IgG, IgM and IgA was reduced significantly. In above various index there was no significant change 30 min after hemorrhagic shock, but two hours after shock the IgG level was reduced, the IgM and IgA level was moderately increased from spleen veinal sampling. The results of spleen tissue hemogenate determination showed that the IgG level was obvious increased, but the IgM and IgA level was moderately reduced, C 3 and C 4 level was increased two hours after hemorrhagic shock. After oxygenated solution resuscitation on hemorrhagic shock, above all indexes improved obviously, the IgG and IgM levels were increased, the C 3 and C 4 levels were reduced. Conclusion The spleen has significant regulatory function on the formation and release of antibody and complement, the hemorrhagic shock may reduce this function and change the condition of humoral immunity; but the treatment of oxygenated hypertonic hypercolloid solution in time may improve the spleen function, and correct the dysequilibrium of humoral immunity, and be hulpful for resuscitation of shock.
