CAJ | 학술논문

目的：建立一个比较接近人类条件的急性肝衰竭模型，用于人工肝脏治疗的疗效和安全性的测试。方法：以右旋半乳糖胺来制造猪肝衰竭的大型动物模型，分3组给药，剂量分别为0．5、1和0．75g/kg。观察其临床表现、生理生化指标和病理改变。结果：3组实验都能引出与人的临床和生化指标变化相近的肝功能衰竭的表现，以0．75g/kg组最为理想。结论：以0．75g/kg的半乳糖胺制造的急性肝功能衰竭的猪动物模型，符合人工肝脏研究对动物模型的要求。
목적：건립일개비교접근인류조건적급성간쇠갈모형，용우인공간장치료적료효화안전성적측시。방법：이우선반유당알래제조저간쇠갈적대형동물모형，분3조급약，제량분별위0．5、1화0．75g/kg。관찰기림상표현、생리생화지표화병리개변。결과：3조실험도능인출여인적림상화생화지표변화상근적간공능쇠갈적표현，이0．75g/kg조최위이상。결론：이0．75g/kg적반유당알제조적급성간공능쇠갈적저동물모형，부합인공간장연구대동물모형적요구。
Aim: To establish a clinically relevant model of fulminant hepatic failure for the test of efficacy and safety of artificial liver support. Methods: We induced a pig model of fulminant hepatic failure by administration of D-galactosamine in the dosage of 0.5 g/kg, 0.75 g/kg and 1 g/kg, and observed the clinical manifestations, biochemical and pathological changes of the diseased pigs. Results: D-galactosamine in the three dosages was able to induce a hepatic failure model, but the dosage of 0.75 g/kg is most suitable for the studies of artificial liver support. Conclusion: A large animal model of fulminant hepatic failure that closely mimics the clinical situation was established.