华中科技大学学报(医学英德文版)
華中科技大學學報(醫學英德文版)
화중과기대학학보(의학영덕문판)
JOURNAL OF TONGJI MEDICAL UNIVERSITY
2002年
4期
281-284
,共4页
Abdel-Moneim Mohamad Salim%石佑恩%韩家军%宁长修
Abdel-Moneim Mohamad Salim%石祐恩%韓傢軍%寧長脩
Abdel-Moneim Mohamad Salim%석우은%한가군%저장수
S. japonicum%rabbit%vertical transmission%congenital infection%IgM
Summary: The aim of the present study was to confirm observations on the vertical transmissionof Schistosoma japonicum in the rabbit. S. japonicum-infected pregnant rabbits were used in thisstudy. Perfusion of mother rabbits was done 9 weeks after infection in order to obtain worm bur-dens in relation to their initial cercarial dose. Anti-schistosoma specific IgM antibodies in serumsamples collected from rabbit kittens were detected by ELISA. Our results showed that gestationperiod lasted the normal 29-31 days. All the exposed mother rabbits became infected with S.japonicum. Positive IgM antibody OD values were detected in 12 out of the 60 kittens examined(20.0 %). In group C and A, 40. 0 % and 17.9 % of the kitten were congenitally infected, re-spectively. 18. i % of the kittens born to mothers infected with a single dose of 200 cercariae perrabbit were positives; this is not significantly different from that obtained for the 600 dose group(22.2 %). Three randomly selected IgM+ kittens harbored between one and two adult worms.The livers of these kittens displayed granulomatous lesions. It is concluded that congenital S.japonicum infection does occur in the rabbit and is affected by the mother stage of pregnancy andto a lesser extent by its infection load.