南京医科大学学报(英文版)
南京醫科大學學報(英文版)
남경의과대학학보(영문판)
JOURNAL OF NANJING MEDICAL UNIVERSITY
2002年
2期
80-84
,共5页
杨明华%张东生%肖尚喜%武影%郑际烈%孔祥银
楊明華%張東生%肖尚喜%武影%鄭際烈%孔祥銀
양명화%장동생%초상희%무영%정제렬%공상은
gingival hyperplasia%genetic locus%histology
Objective To ascertain the histological characteristics of hereditary gingival fibromatosis and the location of HGF gene. Methods A pedigree analysis of HGF was made. The ultrastructure of gingival overgrown tissue was observed by electron microscopy (EMS) and the location of the HGF gene defined with microsatellite markers. Results The HGF consisted of coarse collagen bundles and fibrocytes, epithelial cells, smooth muscle cells, etc. were abnormally arranged; the HGF locus had been mapped to chromosome 5q13-q22. Conclusion The gingival pathological changes resemble "hamartoma" and the findings have implications for identification of the underlying genetic basis of HGF.
