CAJ | 학술논문

Objective To elucidate the expression and cli nical significance of HSP90α in the tissue of human hepatocellular carcinoma. Methods Immunohistochemica l method was used to detect the expression of HSP90α in human hepatocellular ca rcinoma tissue. Results The positive expression rates of HSP90α were 10%, 52.5%, 72.5% in normal liver tissues, adjacent noncancerous liver tissues and hepatocel lular carcinoma tissues, respectively. A significantly higher distribution of HS P90α expression in HCC tissues compared with adjacent noncancerous liver tissu es and normal liver tissues was observed (P＜0.05). HSP90α was correlated to tumor differentiation and capsule (P＜0.05) but not to tumor number (P ＞0.05). It was also correlated to prognosis of HCC. The mean tumor-free sur vival period of patients with HSP90 α-negative was 38.6 months while that of H SP90α-positive was 25.5 months (P＜0.05). Conclusion HSP90α is overexpressed in human hepatocellular carcinoma an d might be used as an indicator to judge the differentiation and prognosis of HC C.