CAJ | 학술논문

目的研究2型糖尿病(T2DM)患者血浆胰岛素水平与轻度认知障碍(MCI)的关系及分析MCI的相关危险因素.方法 T2DM患者101例分为MCI组与NC组.均进行MMSE、GDS、CMS、ADL等评测,并检测Ins、HbA1c、血常规、血脂、肝肾功、血压、心电图、头颅CT等,进行成组t检验、直线相关及Logistic回归分析.结果 (1)糖尿病MCI患者Fins、2hIns、3hIns水平明显升高(P＜0.05).(2)Logistic回归分析最终进入方程的是受教育程度、2hIns水平、高血压、HbA1c.结论高胰岛素血症在糖尿病MCI的发生发展中起重要作用,提高胰岛素的敏感性有利于改善糖尿病患者的认知功能.
목적 연구2형당뇨병(T2DM)환자혈장이도소수평여경도인지장애(MCI)적관계급분석MCI적상관위험인소.방법 T2DM환자101례분위MCI조여NC조.균진행MMSE、GDS、CMS、ADL등평측,병검측Ins、HbA1c、혈상규、혈지、간신공、혈압、심전도、두로CT등,진행성조t검험、직선상관급Logistic회귀분석.결과 (1)당뇨병MCI환자Fins、2hIns、3hIns수평명현승고(P＜0.05).(2)Logistic회귀분석최종진입방정적시수교육정도、2hIns수평、고혈압、HbA1c.결론 고이도소혈증재당뇨병MCI적발생발전중기중요작용,제고이도소적민감성유리우개선당뇨병환자적인지공능.
Objective To investigate the relationship between insulin level and mild cognitive impairment(MCI) of type 2 diabetes and analyze the risk factors for MCI. Methods We collected 101 type 2 diabetes subjects who were divided into two groups:MCI and normal cognition(NC).All subjects were evaluated with cognition scores of MMSE,GDS,CMS,ADL.Insulin,glycosylated hemoglobin,blood routine test,blood pressure,ECG,brain CT were detected.Independent t-test,correlation and multiple regression analysis were performed. Results 1. The diabetic patients with MCI showed the higher levels of insulin at fasting, 2hr and 3hr after meal than did NC(P<0.05).2. Education, insulin level at 2hr after meal,hypertension,and high glucose were variables entering into the equation. Conclusions Hyperinsulinemia contributes to the pathogenesis and development of diabetic MCI