复旦学报（医学版）
複旦學報（醫學版）
복단학보（의학판）
FUDAN UNIVERSITY JOURNAL OF MEDICAL SCIENCES
2009年
4期
461-464
,共4页
毕玮%余优成%潘红芽%田臻%孙健%王庆
畢瑋%餘優成%潘紅芽%田臻%孫健%王慶
필위%여우성%반홍아%전진%손건%왕경
腺样囊性癌%erbB-2%erbB-3%免疫组织化学
腺樣囊性癌%erbB-2%erbB-3%免疫組織化學
선양낭성암%erbB-2%erbB-3%면역조직화학
adenoid cystic carcinoma%erbB-2%erbB-3%immunohistochemistry
目的 通过对erbB-2、erbB-3表达水平与涎腺腺样囊性癌临床病理指标相关性的研究,初步探讨erbB-2、erbB-3在涎腺腺样囊性癌发生、发展及预后中的可能作用.方法 免疫组织化学方法检测34例涎腺腺样囊性癌标本中erbB-2、erbB-3的表达情况,分析其蛋白表达与患者性别、年龄、TNM分期、肿瘤大小、神经侵袭的相关性.结果 erbB-2在腺样囊性癌临床病理标本中的阳性表达率为64.7%,erbB-3阳性率为32.4%,erbB-2/erbB-3双阳性率为29.4%.erbB-3阳性表达与肿瘤TNM分期呈正相关(P=0.026),erbB-2表达与erbB-3表达相关;而erbB-2、erbB-3、erbB-2/erbB-3阳性表达与腺样囊性癌患者性别、年龄、肿瘤大小、神经侵袭无相关性.结论 erbB-3和erbB-2可能均参与了该肿瘤的发生、发展过程;erbB-3阳性表达可能与涎腺腺样囊性癌的生物学行为、患者预后相关,其有可能成为患者预后评价的指标之一.
目的 通過對erbB-2、erbB-3錶達水平與涎腺腺樣囊性癌臨床病理指標相關性的研究,初步探討erbB-2、erbB-3在涎腺腺樣囊性癌髮生、髮展及預後中的可能作用.方法 免疫組織化學方法檢測34例涎腺腺樣囊性癌標本中erbB-2、erbB-3的錶達情況,分析其蛋白錶達與患者性彆、年齡、TNM分期、腫瘤大小、神經侵襲的相關性.結果 erbB-2在腺樣囊性癌臨床病理標本中的暘性錶達率為64.7%,erbB-3暘性率為32.4%,erbB-2/erbB-3雙暘性率為29.4%.erbB-3暘性錶達與腫瘤TNM分期呈正相關(P=0.026),erbB-2錶達與erbB-3錶達相關;而erbB-2、erbB-3、erbB-2/erbB-3暘性錶達與腺樣囊性癌患者性彆、年齡、腫瘤大小、神經侵襲無相關性.結論 erbB-3和erbB-2可能均參與瞭該腫瘤的髮生、髮展過程;erbB-3暘性錶達可能與涎腺腺樣囊性癌的生物學行為、患者預後相關,其有可能成為患者預後評價的指標之一.
목적 통과대erbB-2、erbB-3표체수평여연선선양낭성암림상병리지표상관성적연구,초보탐토erbB-2、erbB-3재연선선양낭성암발생、발전급예후중적가능작용.방법 면역조직화학방법검측34례연선선양낭성암표본중erbB-2、erbB-3적표체정황,분석기단백표체여환자성별、년령、TNM분기、종류대소、신경침습적상관성.결과 erbB-2재선양낭성암림상병리표본중적양성표체솔위64.7%,erbB-3양성솔위32.4%,erbB-2/erbB-3쌍양성솔위29.4%.erbB-3양성표체여종류TNM분기정정상관(P=0.026),erbB-2표체여erbB-3표체상관;이erbB-2、erbB-3、erbB-2/erbB-3양성표체여선양낭성암환자성별、년령、종류대소、신경침습무상관성.결론 erbB-3화erbB-2가능균삼여료해종류적발생、발전과정;erbB-3양성표체가능여연선선양낭성암적생물학행위、환자예후상관,기유가능성위환자예후평개적지표지일.
Objective Through detecting the expression of erbB-2 and erbB-3 of epithelial growth factor receptor family in clinical specimens of salivary adenoid cystic carcinoma, to explore the role of erbB-2 and erbB-3 in the carcinogenesis and development of salivary adenoid cystic carcinoma. Methods Thirty-four specimens of adenoid cystic carcinoma were tested with immunohistochemical assay. Then the relationship between the expressions of erbB-2, erbB-3 and the gender, age of patients, TNM staging, tumor size and nerve invasion were analyzed.Results The positive expression ratios of erbB-2 and erbB-3 were 64. 7% and 32.4% respectively. And 29.4% of tumors were positively stained both by erbB-2 and erbB-3. The expression of erbB-3 was significantly correlated with TNM staging of tumors (P = 0. 026). The correlationship between the expressions of erbB-2 and erbB-3 was also found. Conclusions erbB-3 and erbB-2 may play important roles in the carcinogenesis and development of salivary adenoid cystic carcinoma. The positive expression of erbB-3 was associated with the biological behavior of tumors and prognosis of patients, and might become one of markers to evaluate the prognosis of patients.
