CAJ | 학술논문

目的研究医院内输血后丙型肝炎病毒(HCV)感染的临床流行病特点，探讨改进供血筛检的方法。方法以RT-PCR法对HCV感染的受血及相关供血血清进行HCVRNA定量分析，并检测ALT及抗-HCV。结果致输血后HCV感染的供血中，HCVRNA平均含量为108.65拷贝／L；抗-HCV及ALT的异常检出率及水平随病毒滴度升高而增加。结论低含量HCV供血即可导致输血后感染，病毒含量与抗-HCV阳性及ALT水平有显著正相关，采用ALT加抗-HCV联合筛检供血可明显降低输血后HCV感染。
목적연구의원내수혈후병형간염병독(HCV)감염적림상류행병특점，탐토개진공혈사검적방법。방법이RT-PCR법대HCV감염적수혈급상관공혈혈청진행HCVRNA정량분석，병검측ALT급항-HCV。결과치수혈후HCV감염적공혈중，HCVRNA평균함량위108.65고패／L；항-HCV급ALT적이상검출솔급수평수병독적도승고이증가。결론저함량HCV공혈즉가도치수혈후감염，병독함량여항-HCV양성급ALT수평유현저정상관，채용ALT가항-HCV연합사검공혈가명현강저수혈후HCV감염。
OBJECTIVE To determine the clinical-epidemiologic features ofposttransfusion HCV nosocomial infection and to improve the methods of donor-blood screening.METHODS The qualitative and quantitative HCV RNA in sera were tested,ALT and anti-HCV in serum were tested simultanaeously.RESULTS In serum of donor blood which caused posttranfusion HCV infection,the mean quantity of HCV RNA was 108.65copy／L.The positive rate of anti-HCV in serum was increased with the quantity of HCV RNA.CONCLUSIONS There was a strong correlation between the quantity of HCV RNA and ALT value.Posttransfusion HCV infection could be caused by transfusing blood with low quantity of HCV RNA and exclusion of blood with elevated ALT or positive for anti-HCV could reduce the cases of posttransfusion HCV infection.