CAJ | 학술논문

骨形态发生蛋白(bone morphogenetic proteins,BMPs)是属于TGF-β超家族成员的一组重要细胞因子,参与细胞分化、增殖和胚胎发育等生理过程.不同的BMPs在脊椎动物中具有不同的功能.在信号通路上,BMPs的功能主要由Smad家族蛋白介导,后者包括8个成员,其中Smad1,Smad5和Smad8介导BMPs的信号转导,而Smad2和Smad3介导TGF- β的信号转导.虽然一些BMPs如BMP4和BMP9存在于肝脏,但肝脏中是否存在BMP13尚未有报道.BMP13,又名生长分化因子-6(growth differentiation factor 6,GDF6)或软骨来源的形态生成蛋白-2(cartilage-derived morphogenetic protein 2,CDMP2).研究表明:BMP13参与骨和肌腱的修复,可刺激腱样细胞的增殖.笔者最新的研究结果揭示肝脏组织中有BMP13的表达并在肝脏代谢异常时具有差异表达.本文主要介绍BMP13生物功能研究的最新进展,尤其是BMP13在肝脏中的作用.
골형태발생단백(bone morphogenetic proteins,BMPs)시속우TGF-β초가족성원적일조중요세포인자,삼여세포분화、증식화배태발육등생리과정.불동적BMPs재척추동물중구유불동적공능.재신호통로상,BMPs적공능주요유Smad가족단백개도,후자포괄8개성원,기중Smad1,Smad5화Smad8개도BMPs적신호전도,이Smad2화Smad3개도TGF- β적신호전도.수연일사BMPs여BMP4화BMP9존재우간장,단간장중시부존재BMP13상미유보도.BMP13,우명생장분화인자-6(growth differentiation factor 6,GDF6)혹연골래원적형태생성단백-2(cartilage-derived morphogenetic protein 2,CDMP2).연구표명:BMP13삼여골화기건적수복,가자격건양세포적증식.필자최신적연구결과게시간장조직중유BMP13적표체병재간장대사이상시구유차이표체.본문주요개소BMP13생물공능연구적최신진전,우기시BMP13재간장중적작용.
Bone morphogenetic proteins (BMPs) belong to TGF-β superfamily and are a group of important cytokines involved in cell differentiation,proliferation and embryonic development.Multiple BMPs play important roles in several functions of vertebrates.Signaling pathway of BMPs is known to be mediated by Smad proteins,which include 8 members while Smadl,Smad5 and Smad8 are involved in BMPs signal transduction while Smad2 and Smad3 are mediated TGF-β signal transduction.Although several BMPs such as BMP4 and BMP9 have been documented in the liver,BMP13 has not been examined in the liver.BMP13 also known as growth differentiation factor (GDF)-6 or cartilage-derived morphogenetic protein (CDMP)-2 is one of the BMPs family members.Function of BMP13 has been investigated in bone and tendon repair.It can stimulate tendon-like cell proliferation.However,our recent findings revealed that there was expression of BMP13 in the liver and its expression was modulated during metabolic disorders.The current article is to understand biological function of BMP13 especially in the liver.