CAJ | 학술논문

色氨酸是细胞生长代谢的必需氨基酸,吲哚胺-2,3-双加氧酶是催化色氨酸沿犬尿酸途径分解代谢的限速酶.吲哚胺-2,3-双加氧酶主要通过降解局部微环境中色氨酸,造成色氨酸缺乏,抑制T细胞增生与活化.吲哚胺-2,3-双加氧酶介导的色氨酸代谢中问产物犬尿素、3-羟基犬尿氨酸、3-羟基邻氨基苯甲酸能抑制同种异体T细胞增生.吲哚胺-2,3-双加氧酶树突状细胞与Treg细胞协同作用可能促进免疫耐受的形成.虽然吲哚胺-2,3-双加氧酶介导的色氨酸代谢在移植免疫调节过程中的作用还不甚清楚,但大量的研究表明其诱导移植免疫耐受的应用前景广阔.
색안산시세포생장대사적필수안기산,신타알-2,3-쌍가양매시최화색안산연견뇨산도경분해대사적한속매.신타알-2,3-쌍가양매주요통과강해국부미배경중색안산,조성색안산결핍,억제T세포증생여활화.신타알-2,3-쌍가양매개도적색안산대사중문산물견뇨소、3-간기견뇨안산、3-간기린안기분갑산능억제동충이체T세포증생.신타알-2,3-쌍가양매수돌상세포여Treg세포협동작용가능촉진면역내수적형성.수연신타알-2,3-쌍가양매개도적색안산대사재이식면역조절과정중적작용환불심청초,단대량적연구표명기유도이식면역내수적응용전경엄활.
Tryptophan is the essential amino acid in the growth of cell.Indoleamine 2,3-dioxygenase is the rate-limiting enzyme in the catabolism of tryptophan along the kynurenine pathway.Indoleamine 2,3-dioxygenase enzyme mainly promotes tryptophan consumption of local micro-environment,causing tryptophan lack,thus inhibiting proliferation and activation of T cell.Tryptophan-derived catabolites suppress allogeneic T-cell proliferation (kynurenine,3-hydroxykynurenine,and 3-hydroxyanthranilate).Indoleamine 2,3-dioxygenase dendritic cells may interact with regulatory T cells forming an immunomodulatory network to promote immune tolerance induction.Though the immune regulation mechanism of the indoleamine 2,3-dioxygenase-initiated L-tryptophan in transplantation remains unclear,Numerous researches indicate that its role of tolerance induction in transplantation will be significant.