CAJ | 학술논문

目的探讨新生儿凝血四项功能与分娩方式、体重的关系,分析新生儿凝血生理及其影响因素,为临床提供参考依据.方法取644例不同分娩方式和体重的新生儿的血浆进行凝血四项即凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和凝血酶时间(TT)的测定.结果与对照组相比,顺产组和剖宫产组的第1组凝血四项均明显增加(P＜0.01),第2组PT、APTT延长(P＜0.05)但FIB、TT值无显著差异(P＞0.05),第4组凝血四项均无显著差异(P＞0.05).剖宫产组的第1组与顺产组的第1组相比,PT、APTT延长(P＜0.05),TT、FIB值无显著差异(P＞0.05)；其余相对应组的凝血四项无显著差异(P＞0.05).结论新生儿凝血四项受体重影响,体重越轻凝血时间越长,并随着体重的增加逐渐缩短,纤维蛋白原则逐渐增多;分娩方式主要对体重＜1500g的新生儿的凝血功能有影响.
목적 탐토신생인응혈사항공능여분면방식、체중적관계,분석신생인응혈생리급기영향인소,위림상제공삼고의거.방법 취644례불동분면방식화체중적신생인적혈장진행응혈사항즉응혈매원시간(PT)、활화부분응혈활매시간(APTT)、섬유단백원(FIB)화응혈매시간(TT)적측정.결과 여대조조상비,순산조화부궁산조적제1조응혈사항균명현증가(P＜0.01),제2조PT、APTT연장(P＜0.05)단FIB、TT치무현저차이(P＞0.05),제4조응혈사항균무현저차이(P＞0.05).부궁산조적제1조여순산조적제1조상비,PT、APTT연장(P＜0.05),TT、FIB치무현저차이(P＞0.05)；기여상대응조적응혈사항무현저차이(P＞0.05).결론 신생인응혈사항수체중영향,체중월경응혈시간월장,병수착체중적증가축점축단,섬유단백원칙축점증다;분면방식주요대체중＜1500g적신생인적응혈공능유영향.
Objective To probe into the relationship among the 4 items of blood coagulation with the childbirth fashions and the body weights in neonates.The clinical reference basis was provided to analyze the blood coagulation physiology and influence factors in neonates.Methods The 4 items of blood coagulation,which included prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB) and thrombin time (TT),were determined in plasma for 644 neonates with different childbirth fashions and different body weights.Results Compared with control group,the 4 items of blood coagulation in the first groups (＜1500 g) of natural childbirth and caesarean section group for neonates with different body weights were all obviously extended (P＜0.01); PT,APTT was extended (P＜0.05) and TT,FIB was not apparently changed (P＞0.05) for second group (1500～2500 g),the 4 items of blood coagulation were all not apparendy changed (P＞0.05) for fourth group (＞4000 g).First group of to cut the belly open childbirth was compared with first group of natural childbirth,PT,APTT is extended (P＜0.05) and TT,FIB is not changed (P＞0.05).The 4 items of blood coagulation are not apparently changed (P＞0.05) for other corresponding body weights in caesarean section group and natural childbirth.Conclusions The 4 items of blood coagulation of neonates are affected by body weights.The smaller the body weights,the longer time of the blood coagulation.The blood coagulation times gradually shorten with the increasing body weight,but with FIB gradually increased.The childbirth fashions affect the blood coagulation neonates with the weight ＜1500 g.