CAJ | 학술논문

靶向超声造影剂微泡构建的方法主要有两种方式.靶向新生血管的超声微泡造影剂主要分为连接抗αVβ3抗体、连接αVβ3整合素抗体及连接血管内皮生长因子受体2(VEGFR2)等几种.目前通过靶向微泡黏附于肿瘤靶标的定量分析以及评估黏附于肿瘤新生血管内皮细胞上的靶向微泡与肿瘤局部病理微血管密度之间的相关性认为超声分子成像可以无创、快捷、反复、动态,定量评估肿瘤的微血管生成情况,间接反映恶性肿瘤组织增殖活性及其生物学特性.
파향초성조영제미포구건적방법주요유량충방식.파향신생혈관적초성미포조영제주요분위련접항αVβ3항체、련접αVβ3정합소항체급련접혈관내피생장인자수체2(VEGFR2)등궤충.목전통과파향미포점부우종류파표적정량분석이급평고점부우종류신생혈관내피세포상적파향미포여종류국부병리미혈관밀도지간적상관성인위초성분자성상가이무창、쾌첩、반복、동태,정량평고종류적미혈관생성정황,간접반영악성종류조직증식활성급기생물학특성.
This paper summarizes the new progress of the research of the targeted microbubble ultrasound contrast agents and ultrasound molecular imaging in tumor angiogenesis.There are two constructing methods of targeted microbubble ultrasound contrast agents.Targeted new blood vessels microbubble unltrasound contrast agents are mainly divided into the connection of alpha(V)beta3 antibody,αVβ3 integration antibody and connecting VEGFR2.The quantitative analysis of targeted microbubble adhering to tumor target and the evaluation of the correlation between targeted microbubble adhering to tumor neovascular endothelial cell and tumor local pathological microvessel density suggest that ultrasound molecular imaging can be noninvasive,quick,repeated,dynamic and quantitative evaluate tumor angiogenesis and indirectly reflect the malignant tumor tissue proliferation activity and its biological characteristics.